Regeneration of fat cells from myofibroblasts during wound healing

Maksim Plikus 1, 2, * Christian Guerrero-Juarez 2 Mayumi Ito 3 Yun Rose Li 1 Priya Dedhia 4 Ying Zheng 1 Mengle Shao 5 Denise Gay 1, 6 Raül Ramos 2 Tsai-Ching Hsi 2 Ji Won Oh 2 Xiaojie Wang 2 Amanda Ramirez 2 Sara Konopelski 2 Arijh Elzein 2 Anne Wang 1 Rarinthip June Supapannachart 1 Hye-Lim Lee 2 Chae Ho Lim 3 Arben Nace 1 Amy Guo 1 Elsa Treffeisen 1 Thomas Andl 7 Ricardo Ramirez 2 Rabi Murad 2 Stefan Offermanns 8 Daniel Metzger 9 Pierre Chambon 9 Alan Widgerow 10 Tai-Lan Tuan 11 Ali Mortazavi 2 Rana Gupta 12 Bruce Hamilton 13 Sarah Millar 1 Patrick Seale 14 Warren Pear 4 Mitchell Lazar 15, 1 George Cotsarelis 1
Abstract : Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro. Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.
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Submitted on : Tuesday, October 16, 2018 - 10:46:23 AM
Last modification on : Friday, November 15, 2019 - 10:10:47 AM

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Maksim Plikus, Christian Guerrero-Juarez, Mayumi Ito, Yun Rose Li, Priya Dedhia, et al.. Regeneration of fat cells from myofibroblasts during wound healing. Science, American Association for the Advancement of Science, 2017, 355 (6326), pp.748 - 752. ⟨10.1126/science.aai8792⟩. ⟨cea-01896452⟩

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