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Journal articles
Slow magic-angle coil spinning: A high-sensitivity and high-resolution NMR strategy for microscopic biological specimens
Abstract : High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution 1H NMR spectroscopic approach using magic-angle coil spinning. We demonstrate its potential for intact tissues by combining a resonant microcoil with a large-volume commercial magic-angle spinning rotor, where the microcoil offers incredible sensitivity and the large-volume magic-angle spinning rotor provides stable slow magic-angle spinning. This approach provides high-resolution spectra with high sensitivity and the preservation of living biologic specimens for an accurate chemical analysis.
https://hal-cea.archives-ouvertes.fr/cea-00854518
Contributor : Bruno Savelli <>
Submitted on : Tuesday, August 27, 2013 - 2:34:22 PM
Last modification on : Friday, March 5, 2021 - 3:05:37 PM
Contributor : Bruno Savelli <>
Submitted on : Tuesday, August 27, 2013 - 2:34:22 PM
Last modification on : Friday, March 5, 2021 - 3:05:37 PM
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