Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location

David Castel (1, 2) , Cathy Philippe (3, 1) , Thomas Kergrohen (1, 2) , Martin Sill (4) , Jane Merlevede (1) , Emilie Barret (5, 1) , Stéphanie Puget (6) , Christian Sainte-Rose (7) , Christof Kramm , Chris Jones (8) , Pascale Varlet (9, 10) , Stefan Pfister (11) , Jacques Grill (5, 2, 1) , David Jones (12) , Marie-Anne Debily (13, 1)

1 PMNCO - Prédicteurs moléculaires et nouvelles cibles en oncologie
2 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
3 UNATI - Unité Analyse et Traitement de l'Information
4 Heidelberg University Hospital [Heidelberg]
5 IGR - Institut Gustave Roussy
6 PRES Sorbonne Paris Cité
7 Service de neurochirurgie pédiatrique [CHU Necker]
8 UOR - University of Reading
9 U894 - Centre de Psychiatrie et Neurosciences
10 GHU Paris Psychiatrie et Neurosciences
11 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
12 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
13 UEVE - Université d'Évry-Val-d'Essonne

Domaines: Sciences du Vivant [q-bio]

David Castel, Cathy Philippe, Thomas Kergrohen, Martin Sill, Jane Merlevede, et al.. Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location. Acta Neuropathologica Communications, 2018, 6 (1), pp.117. ⟨10.1186/s40478-018-0614-1⟩. ⟨hal-04515944⟩