EpiBrainRad An epidemiologic study of the neurotoxicity induced by radiotherapy in high grade glioma patients

Thomas Durand (1, 2) , Sophie Jacob (3) , Laura Lebouil (2) , Hassen Douzane (2) , Philippe Lestaevel (4) , Amithys Rahimian (5) , Dimitri Psimaras (2) , Loïc Feuvret (2) , Delphine Leclercq (6) , Bruno Brochet (7) , Radia Tamarat (3) , F. Milliat (3) , Marc Benderitter (3) , Nicolas Vayatis (8) , Georges Noël (9) , Hoang-Xuan Khe (2) , Jean-Yves Delattre (2) , Damien Ricard (2, 5, 1, 10) , Marie-Odile Bernier (11, 12, 13)

1 COGNAC-G - UMR 8257 - Cognition and Action Group
2 CIC Neurosciences - Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière]
3 IRSN/PRP-HOM/SRBE/LRTE - Laboratoire de Radiopathologie et de Thérapies Expérimentales
4 IRSN/PRP-HOM/SRBE/LRTOX - Laboratoire de radiotoxicologie et radiobiologie expérimentale
5 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
6 CHU Pitié-Salpêtrière [AP-HP]
7 Groupe hospitalier Pellegrin
8 LRC MESO - Laboratoire de recheche conventionné MESO
9 FMTS - Fédération de Médecine Translationnelle de Strasbourg
10 Hôpital d'Instruction des Armées du Val de Grâce
11 Service d'Epidémiologie
12 IRSN/PSE-SANTE/SESANE/LEPID - Laboratoire d épidémiologie des rayonnements ionisants
13 UPMC - Université Pierre et Marie Curie - Paris 6

Background Radiotherapy is one of the most important treatments of primary and metastatic brain tumors. Unfortunately, it can involve moderate to severe complications among which leukoencephalopathy is very frequent and implies cognitive deficits such as memory, attention and executive dysfunctions. However, the incidence of this complication is not well established and the risk factors and process are poorly understood. The main objective of the study is to improve knowledge on radio-induced leukoencephalopathy based on pluridisciplinar approaches combining cognitive, biologic, imagery and dosimetric investigations. Method/Design The EpiBrainRad study is a prospective cohort study including newly diagnosed high grade gliomas patients treated by radiotherapy and concomitant-adjuvant temozolomide chemotherapy. Patients are included between their surgery and first day of radio-chemotherapy, and the follow-up lasts for 3 years after treatment. Cognitive functioning assessments, specific blood biomarkers measures and magnetic resonance imagery are performed at different moment during the follow-up, and a specific dosimetric assessment of organs involved in the beam fields is performed. Firstly, leukoencephalopathy incidence rate will be estimated in this population. Secondly, correlations between cognitive impairments and dosimetry, biomarkers ranges and anomalies on imagery will be analyzed in order to better understand the onset and evolution of cognitive decrement associated with radiotherapy. Furthermore, a new cognitive test, quickly and easily performed, will be studied to determine its sensibility to detect leukoencephalopathy decrement. Discussion With an original multidisciplinary approach, the EpiBrainRad study aims to improve knowledge on radio-induced leukoencephalopathy in order to improve its early diagnosis and prevention. The main challenge is to preserve quality-of-life after cancer treatments which imply to study the incidence of radiation-induced complications and their associated risk factors.

Domaines: Sciences du Vivant [q-bio]

Thomas Durand, Sophie Jacob, Laura Lebouil, Hassen Douzane, Philippe Lestaevel, et al.. EpiBrainRad An epidemiologic study of the neurotoxicity induced by radiotherapy in high grade glioma patients. BMC Neurology, 2015, 15 (1), pp.261. ⟨10.1186/s12883-015-0519-6⟩. ⟨hal-02572573⟩