A passive microfluidic device for plasma extraction from whole human blood

E. Sollier , M. Cubizolles (1) , M. Faivre (2) , Y. Fouillet (3) , J.L. Achard

1 DTBS - Département Microtechnologies pour la Biologie et la Santé
2 Service d'Hépatologie [CHRU Besançon]
3 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information

Promising microfluidic devices are proposed herein to continuously and passively extract plasma from whole human blood. These designs are based on the red cells lateral migration and the resulting cell-free layer locally expanded by geometric singularities, such as an abrupt enlargement of the channel or a cavity adjacent to the channel. After an explanation of flow patterns, devices are experimentally and biologically validated for plasma extraction. They are also successively optimized with extraction yields up to 17.8% for a 1:20 blood injected at 100 muL/min.

Domaines: Micro et nanotechnologies/Microélectronique; Biophysique [physics.bio-ph]; Biomécanique [physics.med-ph]; Mécanique des fluides [physics.class-ph]

E. Sollier, M. Cubizolles, M. Faivre, Y. Fouillet, J.L. Achard. A passive microfluidic device for plasma extraction from whole human blood. 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Sep 2009, Minneapolis, United States. ⟨10.1109/IEMBS.2009.5333314⟩. ⟨hal-01870732⟩