N-[18F]-FluoropropylJDTic for κ-opioid receptor PET imaging : Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic.

S Schmitt (1) , J Delamare (1) , O Tirel (1) , F Fillesoye (1) , M Dhilly (1) , C Perrio (1)

1 LDM-TEP - Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons

Mots clés: N-fluoroalkylation; PET imaging; Metabolism; kappa Opioid receptor; JDTic; Fluorine-18

Domaines: Sciences du Vivant [q-bio]; Radiochimie

S Schmitt, J Delamare, O Tirel, F Fillesoye, M Dhilly, et al.. N-[18F]-FluoropropylJDTic for κ-opioid receptor PET imaging : Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic.. Nuclear Medicine and Biology, 2017, 44, pp.50-61. ⟨10.1016/j.nucmedbio.2016.09.005⟩. ⟨hal-01575523⟩