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Rôles du locus bric à brac durant la formation des niches de cellules souches germinales dans l'ovaire chez Drosophila melanogaster

Abstract : The interactions between stem cells (SC) and their microenvironment called a niche are known to be crucial for SC behaviour. These interactions need to be highly regulated since abnormal SC behaviour is a leading cause of developmental diseases and tumourigenesis. The discovery of pre-metastatic niches makes the study of niche-to-SC interactions a crucial step for our understanding of cancer biology. The powerful genetic tools available render the Drosophila ovary an excellent model to study the signalling controlling germline SC (GSC) maintenance by a niche in an adult tissue. Using this model, it was shown for the first time that SC maintenance was dependent on a factor emanating from the niche. This factor is Decapentaplegic (Dpp), a Drosophila homolog of BMP proteins (family of TGF-β signalling molecules) and a tight regulation of this signalling pathway is very important to avoid an excess of GSC-like cells (tumour) or a loss of GSCs (sterility). Formation of the GSC niches occurs during the larval stages and the bric-à-brac (bab) locus was first discovered as being necessary for niche morphogenesis. During my doctoral studies, I have shown that Bab1 and Bab2 are necessary and sufficient for GSC recruitment by regulating dpp expression, and some of my results alos suggest that GSC recruitment might occurs according to a different mechanism that the one involved in their maintenance (Miscopein-Saler et al,. in preparation).
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  • HAL Id : tel-03712007, version 1

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Laurine Miscopein Saler. Rôles du locus bric à brac durant la formation des niches de cellules souches germinales dans l'ovaire chez Drosophila melanogaster. Biologie cellulaire. Université Paris Saclay (COmUE), 2018. Français. ⟨NNT : 2018SACLS599⟩. ⟨tel-03712007⟩

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