Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway

Laurene Abjean (1) , Lucile Ben Haim (1) , Miriam Riquelme-Perez (1, 2) , Pauline Gipchtein (1) , Céline Derbois (2) , Marie-Ange Palomares (2) , Fanny Petit (1) , Anne-Sophie Hérard (1) , Marie-Claude Gaillard (1) , Martine Guillermier (1) , Mylène Gaudin-Guérif (1) , Gwennaëlle Aurégan (1) , Nisrine Sagar (1) , Cameron Héry (1) , Noëlle Dufour (1) , Noémie Robil (3) , Mehdi Kabani (1) , Ronald Melki (1) , Pierre De La Grange (3) , Alexis P Bemelmans (1) , Gilles Bonvento (1) , Jean-François Deleuze (2) , Philippe Hantraye (1) , Julien Flament (1) , Eric Bonnet (2) , Solène Brohard (2) , Robert Olaso (2) , Emmanuel Brouillet (1) , Maria-Angeles Carrillo-de Sauvage (1) , Carole Escartin (1)

1 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
2 CNRGH - Centre National de Recherche en Génomique Humaine
3 GenoSplice [Paris]

Mots clés: neuron-astrocyte interactions; JAK2-STAT3 signalling; aggregated protein clearance; viral vectors; neurodegenerative diseases

Domaines: Neurosciences [q-bio.NC]

Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, et al.. Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway. Brain - A Journal of Neurology , 2022, ⟨10.1093/brain/awac068/6550082⟩. ⟨cea-03872742⟩