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Disease mechanisms of multiple system atrophy: What a pParallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us

Abstract : Intracellular deposits rich in aggregated alpha-synuclein that appear within the central nervous system are intimately associated to Parkinson's disease and multiple system atrophy. While it is understandable that the aggregation of proteins, which share no primary structure identity, such as alpha-synuclein and tau protein, leads to different diseases, that of a given protein yielding distinct pathologies is counterintuitive. This short review relates molecular and mechanistic processes to the observed pathological diversity associated to alpha-synuclein aggregation.
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https://hal-cea.archives-ouvertes.fr/cea-03827567
Contributor : Ronald Melki Connect in order to contact the contributor
Submitted on : Monday, October 24, 2022 - 5:11:42 PM
Last modification on : Thursday, October 27, 2022 - 3:43:06 AM

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Ronald Melki. Disease mechanisms of multiple system atrophy: What a pParallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us. The Cerebellum, 2022, 2022, ⟨10.1007/s12311-022-01417-0⟩. ⟨cea-03827567⟩

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