Disease mechanisms of multiple system atrophy: What a pParallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us

Ronald Melki (1, 2)

1 CEA - CEA- Saclay
2 MIRCEN - Service MIRCEN

Intracellular deposits rich in aggregated alpha-synuclein that appear within the central nervous system are intimately associated to Parkinson's disease and multiple system atrophy. While it is understandable that the aggregation of proteins, which share no primary structure identity, such as alpha-synuclein and tau protein, leads to different diseases, that of a given protein yielding distinct pathologies is counterintuitive. This short review relates molecular and mechanistic processes to the observed pathological diversity associated to alpha-synuclein aggregation.

Keywords: Protein folding; Alpha-synuclein aggregation; Fibrillar polymorphism; Multiple system atrophy; Parkinson's disease

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology

Ronald Melki. Disease mechanisms of multiple system atrophy: What a pParallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us. The Cerebellum, 2022, 2022, ⟨10.1007/s12311-022-01417-0⟩. ⟨cea-03827567⟩