Alkyl Formates as Transfer Hydroalkylation Reagents and Their Use in the Catalytic Conversion of Imines to Alkylamines - Archive ouverte HAL Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2022

Alkyl Formates as Transfer Hydroalkylation Reagents and Their Use in the Catalytic Conversion of Imines to Alkylamines

Abstract

Easily accessible via a simple esterification of alcohols with formic acid, alkyl formates are used as a novel class of transfer hydroalkylation reagents, CO2 acting as a traceless linker. As a proof-of-concept, their reactivity in the transfer hydroalkylation of imines is investigated, using a ruthenium-based catalyst and LiI as promoter to cleave the C−O σ–bond of the formate scaffold. Providing tertiary amines, the reaction displays a divergent regioselectivity compared to previously reported transfer hydroalkylation strategies.
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Dates and versions

cea-03826192 , version 1 (24-10-2022)

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Etienne Crochet, Lucile Anthore-Dalion, Thibault Cantat. Alkyl Formates as Transfer Hydroalkylation Reagents and Their Use in the Catalytic Conversion of Imines to Alkylamines. Angewandte Chemie International Edition, 2022, ⟨10.1002/anie.202214069⟩. ⟨cea-03826192⟩
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