Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$

Alexia Ohleier (1, 2, 3) , Antoine Sallustrau (2) , Bouchaib Mouhsine (2) , Fabien Caillé (3) , Davide Audisio (2) , Thibault Cantat (1)

1 LCMCE - Laboratoire de Chimie Moléculaire et de Catalyse pour l'Energie (ex LCCEF)
2 SCBM - Service de Chimie Bio-Organique et de Marquage
3 BIOMAPS - LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay

The functionalization of carbon dioxide (CO2) into high-value building blocks is a relevant topic in carbon isotope labeling, where CO2 is the primary carbon source. A catalytic methoxylation of aryl halides directly from 13C and 14C CO2 is reported. Relying on the intermediacy of the methoxyborane BBN-OCH3, as new secondary nucleophilic labeled source, this strategy allowed labeling of a series of substrates, including challenging pharmaceuticals containing tertiary alkyl amine substituents.

Domains: Chemical Sciences; Catalysis; Chemical Sciences; Organic chemistry

Alexia Ohleier, Antoine Sallustrau, Bouchaib Mouhsine, Fabien Caillé, Davide Audisio, et al.. Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$. Chemical Communications, In press, 58, pp.12831-12834. ⟨10.1039/D2CC03746G⟩. ⟨cea-03809925⟩