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Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$

Abstract : The functionalization of carbon dioxide (CO2) into high-value building blocks is a relevant topic in carbon isotope labeling, where CO2 is the primary carbon source. A catalytic methoxylation of aryl halides directly from 13C and 14C CO2 is reported. Relying on the intermediacy of the methoxyborane BBN-OCH3, as new secondary nucleophilic labeled source, this strategy allowed labeling of a series of substrates, including challenging pharmaceuticals containing tertiary alkyl amine substituents.
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https://hal-cea.archives-ouvertes.fr/cea-03809925
Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Tuesday, October 11, 2022 - 7:41:01 AM
Last modification on : Tuesday, November 22, 2022 - 8:43:30 AM

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Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

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Alexia Ohleier, Antoine Sallustrau, Bouchaib Mouhsine, Fabien Caillé, Davide Audisio, et al.. Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$. Chemical Communications, In press, 58, pp.12831-12834. ⟨10.1039/D2CC03746G⟩. ⟨cea-03809925⟩

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