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Serial small- and wide-angle X-ray scattering with laboratory sources

Abstract : Recent advances in X-ray instrumentation and sample injection systems have enabled serial crystallography of protein nanocrystals and the rapid structural analysis of dynamic processes. However, this progress has been restricted to large-scale X-ray free-electron laser (XFEL) and synchrotron facilities, which are often oversubscribed and have long waiting times. Here, we explore the potential of state-of-the-art laboratory X-ray systems to perform comparable analyses when coupled to micro- and millifluidic sample environments. Our results demonstrate that commercial small- and wide-angle X-ray scattering (SAXS/WAXS) instruments and X-ray diffractometers are ready to access samples and timescales (≳5 ms) relevant to many processes in materials science including the preparation of pharmaceuticals, nanoparticles and functional crystalline materials. Tests of different X-ray instruments highlighted the importance of the optical configuration and revealed that serial WAXS/XRD analysis of the investigated samples was only possible with the higher flux of a microfocus setup. We expect that these results will also stimulate similar developments for structural biology.
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Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Monday, August 22, 2022 - 3:03:17 PM
Last modification on : Thursday, August 25, 2022 - 3:28:07 AM


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Mark A Levenstein, Karen Robertson, Thomas D Turner, Liam Hunter, Cate O'Brien, et al.. Serial small- and wide-angle X-ray scattering with laboratory sources. International Union of Crystallography journal, International Union of Crystallography 2022, 9 (5), ⟨10.1107/S2052252522007631⟩. ⟨cea-03757323⟩



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