Amyloid polymorphs and pathological diversities

Ronald Melki (1, 2)

1 CEA - CEA- Saclay
2 MIRCEN - Molecular Imaging Research Center [Fontenay-aux-Roses]

The presence of protein aggregates within the central nervous system is intimately associated to debilitating neurodegenerative diseases. While the aggregation of proteins, that share no primary structure identity, is understandable in different diseases, that of a given protein yielding distinct pathologies is counterintuitive. This short review relates molecular and mechanistic processes to the observed pathological diversity.

Domaines: Neurobiologie

Ronald Melki. Amyloid polymorphs and pathological diversities. Neurochemistry International, 2022, 156, ⟨10.1016/j.neuint.2022.105335⟩. ⟨cea-03683748⟩