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Catalytic and photoresponsive BiZ/Cu x S heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections

Abstract : Copper/bismuth sulfide heterojunctions boost the catalytic and photoresponsive properties engendered antibacterial activity against clinically isolated multidrug-resistant bacteria and their associated biofilms. We report a one-pot facile synthesis of highly photoresponsive bovine serum albumin (BSA) templated bismuth-copper sulfide nanocomposites (BSA-BiZ/CuxS NCs, where BiZ represents in situ formed Bi2S3 and bismuth oxysulfides (BOS)). As-formed surface vacancies and BiZ/CuxS heterojunctions impart superior catalytic, photodynamic and photothermal properties. Upon near-infrared (NIR) irradiation, the BSA-BiZ/CuxS NCs exhibit broad-spectrum antibacterial activity, not only against standard multidrug-resistant (MDR) bacterial strains but also against clinically isolated MDR bacteria and their associated biofilms. The minimum inhibitory concentration of BSA-BiZ/CuxS NCs is 14-fold lower than that of BSA-CuxS NCs because their multiple heterojunctions and vacancies facilitated an amplified phototherapeutic response. As-prepared BSA-BiZ/CuxS NCs exhibited substantial biofilm inhibition (90%) and eradication (>75%) efficiency under NIR irradiation. Furthermore, MRSA-infected diabetic mice were immensely treated with BSA-BiZ/CuxS NCs coupled with NIR irradiation by destroying the mature biofilm on the wound site, which accelerated the wound healing process via collagen synthesis and epithelialization. We demonstrate that BSA-BiZ/CuxS NCs with superior antimicrobial activity and high biocompatibility hold great potential as an effective photosensitive agent for the treatment of biofilm-associated infections.
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https://hal-cea.archives-ouvertes.fr/cea-03610754
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Submitted on : Wednesday, March 16, 2022 - 3:59:24 PM
Last modification on : Friday, April 1, 2022 - 3:50:53 AM

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Amit Nain, Hao-Hsin Huang, Daniel Chevrier, Yu-Ting Tseng, Arumugam Sangili, et al.. Catalytic and photoresponsive BiZ/Cu x S heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections. Nanoscale, Royal Society of Chemistry, 2021, 13 (44), pp.18632-18646. ⟨10.1039/d1nr06358h⟩. ⟨cea-03610754⟩

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