Skip to Main content Skip to Navigation
Journal articles

Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation

Pujiang Shi 1 Chiew Kei Tan 1 Zhuoran Wu 1 Jean-Christophe Gabriel 2, 1 Madhavi Srinivasan 1, 1 Jong-Min Lee 1, 3 Chor Yong Tay 1, 1, 1, * 
* Corresponding author
2 LICSEN - Laboratoire Innovation en Chimie des Surfaces et NanoSciences
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : Reuse of electronic wastes is a critical aspect for a more sustainable circular economy as it provides the simplest and most direct route to extend the lifespan of non-renewable resources. Herein, the distinctive surface and micro topographical features of computer electronic-plastic (E-plastic) scraps were unconventionally repurposed as a substrate material to guide the growth and differentiation of human adipose-derived mesenchymal stem cells (ADSCs). Specifically, the E-plastics were scavenged from discarded computer components such as light diffuser plate (polyacrylates), prismatic sheet (polyethylene terephthalate), and keyboards (acrylonitrile butadiene styrene) were cleaned, sterilized, and systematically characterized to determine the identity of the plastics, chemical constituents, surface features, and leaching characteristics. Multiparametric analysis revealed that all the E-plastics could preserve stem-cell phenotype and maintain cell growth over 2 weeks, rivalling the performance of commercial tissue-culture treated plates as cell culture plastics. Interestingly, compared to commercial tissue-culture treated plastics and in a competitive adipogenic and osteogenic differentiation environment, ADSCs cultured on the keyboard and light diffuser plastics favoured bone cells formation while the grating-like microstructures of the prismatic sheet promoted fat cells differentiation via the process of contact guidance. Our findings point to the real possibility of utilizing discarded computer plastics as a “waste-to-resource” material to programme stem cell fate without further processing nor biochemical modification, thus providing an innovative second-life option for E-plastics from personal computers.
Document type :
Journal articles
Complete list of metadata
Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Tuesday, November 2, 2021 - 8:59:19 AM
Last modification on : Tuesday, August 23, 2022 - 4:18:53 PM
Long-term archiving on: : Thursday, February 3, 2022 - 6:22:50 PM


Files produced by the author(s)



Pujiang Shi, Chiew Kei Tan, Zhuoran Wu, Jean-Christophe Gabriel, Madhavi Srinivasan, et al.. Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation. Science of the Total Environment, Elsevier, In press, 2021 (807), pp.151085. ⟨10.1016/j.scitotenv.2021.151085⟩. ⟨cea-03411164⟩



Record views


Files downloads