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Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

Abstract : With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of α-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define α-synuclein’s varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD.
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https://hal-cea.archives-ouvertes.fr/cea-03308380
Contributor : Ronald Melki Connect in order to contact the contributor
Submitted on : Thursday, July 29, 2021 - 6:10:15 PM
Last modification on : Wednesday, August 4, 2021 - 3:34:03 AM
Long-term archiving on: : Saturday, October 30, 2021 - 6:38:08 PM

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Luis Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, et al.. Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. npj Parkinson's Disease, Nature, 2021, 7, ⟨10.1038/s41531-021-00203-9⟩. ⟨cea-03308380⟩

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