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A microfluidic dosimetry cell to irradiate solutions with poorly penetrating radiations: a step towards online dosimetry for synchrotron beamlines

Abstract : Synchrotron radiation can induce sample damage, whether intended or not. In the case of sensitive samples, such as biological ones, modifications can be significant. To understand and predict the effects due to exposure, it is necessary to know the ionizing radiation dose deposited in the sample. In the case of aqueous samples, deleterious effects are mostly induced by the production of reactive oxygen species via water radiolysis. These species are therefore good indicators of the dose. Here the application of a microfluidic cell specifically optimized for low penetrating soft X-ray radiation is reported. Sodium benzoate was used as a fluorescent dosimeter thanks to its specific detection of hydroxyl radicals, a radiolytic product of water. Measurements at 1.28 keV led to the determination of a hydroxyl production yield, G (HO . ), of 0.025 ± 0.004 µmol J −1 . This result is in agreement with the literature and confirms the high linear energy transfer behavior of soft X-rays. An analysis of the important parameters of the microfluidic dosimetry cell, as well as their influences over dosimetry, is also reported.
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https://hal-cea.archives-ouvertes.fr/cea-03202522
Contributor : Serge Palacin <>
Submitted on : Tuesday, April 20, 2021 - 8:02:55 AM
Last modification on : Friday, April 23, 2021 - 3:16:06 AM

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Lucie Huart, Christophe Nicolas, Marie-Anne Hervé Du Penhoat, Jean-Michel Guigner, Charlie Gosse, et al.. A microfluidic dosimetry cell to irradiate solutions with poorly penetrating radiations: a step towards online dosimetry for synchrotron beamlines. Journal of Synchrotron Radiation, International Union of Crystallography, In press, 28 (3), ⟨10.1107/S1600577521002691⟩. ⟨cea-03202522⟩

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