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radiochimie et chimie sous rayonnement vivant et santé Comprendre et améliorer les effets cliniques de la hadronthérapie

Pauline Maury 1 Erika Porcel 1 Sandrine Lacombe 1 Gérard Baldacchino 2
2 DICO - Biomolécules Excitées
IRAMIS - Institut Rayonnement Matière de Saclay, LIDyl - Laboratoire Interactions, Dynamiques et Lasers (ex SPAM)
Abstract : Charged particles beams allowed to improve targeting and effectiveness of radiotherapy treatments. On the one hand, it reduces toxicities induced in the sensitive organs. On the other hand, it increases local control, in particular of radioresistant cancers. Better knowledge of the effects of linear energy transfer (LET), particularly at the Bragg peak, and of water radiolysis have advanced this treatment method. However, many scientific and technical obstacles still need to be resolved to move towards personalized particle therapy (hadrontherapy) treatments. For example, the effectiveness of treatments can be further improved by associating nanoparticles with elevated LET radiations. The current research ranges from particles physics and fundamental chemistry to clinical trials involving different research teams worldwide.
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https://hal-cea.archives-ouvertes.fr/cea-03187597
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Submitted on : Thursday, April 1, 2021 - 11:07:09 AM
Last modification on : Thursday, July 1, 2021 - 4:48:46 PM

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  • HAL Id : cea-03187597, version 1

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Pauline Maury, Erika Porcel, Sandrine Lacombe, Gérard Baldacchino. radiochimie et chimie sous rayonnement vivant et santé Comprendre et améliorer les effets cliniques de la hadronthérapie. L'Actualité Chimique, Société chimique de France, 2021, 460-461, pp.76-83. ⟨cea-03187597⟩

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