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Xe Ultrafast Z-spectroscopy enables micromolar detection of biosensors on a 1T benchtop spectrometer

Kévin Chighine 1 Estelle Léonce 1 Céline Boutin 1 Hervé Desvaux 1 Patrick Berthault 1, *
* Corresponding author
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : The availability of a benchtop NMR spectrometer, of low cost and easily transportable, can allow detection of low quantities of biosensors, provided that hyperpolarized species are used. Here we show that the micromolar threshold can easily be reached, by employing laser-polarized xenon and cage-molecules reversibly hosting it. Indirect detection of caged xenon is made via chemical exchange, using ultrafast Z-spectroscopy based on spatio-temporal encoding. On this non-dedicated low-field spectrometer, several ideas are proposed to improve the signal.
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https://hal-cea.archives-ouvertes.fr/cea-03182749
Contributor : Serge Palacin <>
Submitted on : Friday, March 26, 2021 - 3:44:53 PM
Last modification on : Friday, April 23, 2021 - 3:16:05 AM

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  • HAL Id : cea-03182749, version 1

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Kévin Chighine, Estelle Léonce, Céline Boutin, Hervé Desvaux, Patrick Berthault. Xe Ultrafast Z-spectroscopy enables micromolar detection of biosensors on a 1T benchtop spectrometer. Magnetic Resonance, Groupement Ampere - Copernicus Publications, In press. ⟨cea-03182749⟩

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