Skip to Main content Skip to Navigation
Journal articles

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils

Abstract : Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanisms of propagation. As such, the prion-like spreading of protein aggregates through the neural network is subject of intensive research focus and requires adequate models. Here, we made use of the well-defined architecture and large accessibility of the visual system, of which the retinotopic connections represent a simple route of anterograde signaling and an elegant model to investigate transsynaptic, prion-like spreading. In two independent studies, uptake and seeding of alpha-synuclein and tau were examined after intravitreal injection of preformed fibrils. However, extracellular matrix components in the vitreous space and at the vitreoretinal surface appeared to act as a barrier for the entry of both fibrils into the retina. These results show that further experimental refinement is needed to fully realize the potential of the visual system as a model for studying the molecular and cellular mechanisms of anterograde, transsynaptic spreading of prion-like proteins.
Document type :
Journal articles
Complete list of metadata

https://hal-cea.archives-ouvertes.fr/cea-03116130
Contributor : Ronald Melki Connect in order to contact the contributor
Submitted on : Wednesday, January 20, 2021 - 10:02:08 AM
Last modification on : Friday, January 22, 2021 - 3:30:15 AM
Long-term archiving on: : Wednesday, April 21, 2021 - 6:18:09 PM

File

fnagi-12-614587.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Lien Veys, Jessie van Houcke, Jeroen Aerts, Sophie van Pottelberge, Michel Mahieu, et al.. Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils. Frontiers in Aging Neuroscience, Frontiers, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩. ⟨cea-03116130⟩

Share

Metrics

Record views

26

Files downloads

56