Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation

Antonio del Vecchio; Alex Talbot; Fabien Caillé; Arnaud Chevalier; Antoine Sallustrau; Olivier Loreau; Gianluca Destro; Frédéric Taran; Davide Audisio

doi:10.1039/D0CC05031H

Journal articles

Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation

Antonio del Vecchio ^{1, 2} Alex Talbot ^{2, 1} Fabien Caillé ^{3, 2} Arnaud Chevalier ^{1, 4, 2} Antoine Sallustrau ^{1, 2} Olivier Loreau ^{1, 2} Gianluca Destro ^{1, 2} Frédéric Taran ^{1, 2} Davide Audisio ^{1, 2, *}

* Corresponding author

1 SCBM - Service de Chimie Bio-Organique et de Marquage

2 Université Paris-Saclay

3 IMIV - U1023 - ERL9218 - Imagerie Moléculaire in Vivo

4 ICSN - Institut de Chimie des Substances Naturelles

Abstract : A general procedure for the late-stage[$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.

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Journal articles

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Chemical Sciences / Organic chemistry

Chemical Sciences / Radiochemistry

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Submitted on : Tuesday, September 8, 2020 - 10:14:16 PM
Last modification on : Friday, May 6, 2022 - 3:42:48 AM
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Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation

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Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation

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