Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation

Antonio del Vecchio (1, 2) , Alex Talbot (2, 1) , Fabien Caillé (3, 2) , Arnaud Chevalier (1, 4, 2) , Antoine Sallustrau (1, 2) , Olivier Loreau (1, 2) , Gianluca Destro (1, 2) , Frédéric Taran (1, 2) , Davide Audisio (1, 2)

1 SCBM - Service de Chimie Bio-Organique et de Marquage
2 Université Paris-Saclay
3 IMIV - U1023 - ERL9218 - Imagerie Moléculaire in Vivo
4 ICSN - Institut de Chimie des Substances Naturelles

A general procedure for the late-stage[$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Radiochemistry

Antonio del Vecchio, Alex Talbot, Fabien Caillé, Arnaud Chevalier, Antoine Sallustrau, et al.. Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation. Chemical Communications, In press, ⟨10.1039/D0CC05031H⟩. ⟨cea-02933909⟩