Robust Grafting of Polyionenes: New Potent and Versatile Antimicrobial Surfaces - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue Macromolecular Bioscience Année : 2020

Robust Grafting of Polyionenes: New Potent and Versatile Antimicrobial Surfaces

Résumé

Polyionenes (PI) with stable positive charges and tunable hydrophobic spacers in the polymer backbone, are shown to be particularly efficient regarding antimicrobial properties. This effect can be modulated since it increases with the length of hydrophobic spacers, i.e., the number of methylene groups between quaternary ammoniums. Now, to further explore these properties and provide efficient antimicrobial surfaces, polyionenes should be grafted onto materials. Here a robust grafting strategy to covalently attach polyionenes is described. The method consisted in a sequential surface chemistry procedure combining polydopamine coating, diazonium-induced polymerization, and polyaddition. To the best of knowledge, grafting of PI onto surfaces is not reported earlier. All chemical steps are characterized in detail via various surface analysis techniques (FTIR, X-ray photoelectron spectroscopy, contact angle, and surface energy measurements). The antibacterial properties of polyionene-grafted surfaces are then studied through bacterial adhesion experiments consisting in enumeration of adherent bacteria (total and viable cultivable cells). PI-grafted surfaces are showed to display effective and versatile bacteriostatic/bactericidal properties associated with a proadhesive effect.
Fichier non déposé

Dates et versions

cea-02909781 , version 1 (31-07-2020)

Identifiants

Citer

Sarah Bernardi, Margareth Renault, Antoine Malabirade, Nabila Debou, Jocelyne Leroy, et al.. Robust Grafting of Polyionenes: New Potent and Versatile Antimicrobial Surfaces. Macromolecular Bioscience, 2020, 20 (10), pp.2000157. ⟨10.1002/mabi.202000157⟩. ⟨cea-02909781⟩
183 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More