Skip to Main content Skip to Navigation
Journal articles

Robust Grafting of Polyionenes: New Potent and Versatile Antimicrobial Surfaces

Abstract : Polyionenes (PI) with stable positive charges and tunable hydrophobic spacers in the polymer backbone, are shown to be particularly efficient regarding antimicrobial properties. This effect can be modulated since it increases with the length of hydrophobic spacers, i.e., the number of methylene groups between quaternary ammoniums. Now, to further explore these properties and provide efficient antimicrobial surfaces, polyionenes should be grafted onto materials. Here a robust grafting strategy to covalently attach polyionenes is described. The method consisted in a sequential surface chemistry procedure combining polydopamine coating, diazonium-induced polymerization, and polyaddition. To the best of knowledge, grafting of PI onto surfaces is not reported earlier. All chemical steps are characterized in detail via various surface analysis techniques (FTIR, X-ray photoelectron spectroscopy, contact angle, and surface energy measurements). The antibacterial properties of polyionene-grafted surfaces are then studied through bacterial adhesion experiments consisting in enumeration of adherent bacteria (total and viable cultivable cells). PI-grafted surfaces are showed to display effective and versatile bacteriostatic/bactericidal properties associated with a proadhesive effect.
Document type :
Journal articles
Complete list of metadata
Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Friday, July 31, 2020 - 10:54:08 AM
Last modification on : Friday, August 5, 2022 - 2:41:13 PM



Sarah Bernardi, Margareth Renault, Antoine Malabirade, Nabila Debou, Jocelyne Leroy, et al.. Robust Grafting of Polyionenes: New Potent and Versatile Antimicrobial Surfaces. Macromolecular Bioscience, Wiley-VCH Verlag, 2020, 20 (10), pp.2000157. ⟨10.1002/mabi.202000157⟩. ⟨cea-02909781⟩