The biology of proteostasis in aging and disease, Annual review of biochemistry, vol.84, pp.435-464, 2015. ,
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade, Annual review of biochemistry, vol.86, pp.27-68, 2017. ,
Prion-like transmission of protein aggregates in neurodegenerative diseases, Nature reviews. Molecular cell biology, vol.11, pp.301-307, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-01183206
Tau pathology and neurodegeneration, Lancet Neurol, vol.12, pp.609-622, 2013. ,
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease, Neuron, vol.3, pp.519-526, 1989. ,
Biochemistry and cell biology of tau protein in neurofibrillary degeneration, Cold Spring Harb Perspect Med, vol.2, p.6247, 2012. ,
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding, Neuron, vol.11, pp.153-163, 1993. ,
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders, Nat Rev Neurosci, vol.8, pp.663-672, 2007. ,
, Unconventional Secretion Mediates the Trans-cellular Spreading of Tau. Cell reports, vol.23, pp.2039-2055, 2018.
Modulation of Amyloid States by Molecular Chaperones, Cold Spring Harb Perspect Biol, vol.11, 2019. ,
Pathways of cellular proteostasis in aging and disease, The Journal of cell biology, vol.217, pp.51-63, 2018. ,
Chaperone machines for protein folding, unfolding and disaggregation, Nature reviews. Molecular cell biology, vol.14, pp.630-642, 2013. ,
The HSP70 chaperone machinery: J proteins as drivers of functional specificity, Nature reviews. Molecular cell biology, vol.11, pp.579-592, 2010. ,
In vivo aspects of protein folding and quality control, Science, vol.353, p.4354, 2016. ,
The Hsp70 chaperone network, Nature Reviews Molecular Cell Biology, vol.20, pp.665-680, 2019. ,
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.30, pp.15374-15382, 2010. ,
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation, Nat Struct Mol Biol, vol.25, pp.384-393, 2018. ,
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport, Biochemistry, vol.50, pp.10300-10310, 2011. ,
Hsp70 alters tau function and aggregation in an isoform specific manner, Biochemistry, vol.51, pp.888-898, 2012. ,
The nucleotide exchange factors of Hsp70 molecular chaperones, Front Mol Biosci, vol.2, 2015. ,
Human Hsp70 Disaggregase Reverses Parkinson's-Linked alpha-Synuclein Amyloid Fibrils, Molecular cell, vol.59, pp.781-793, 2015. ,
The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?, Acta Neuropathol Commun, vol.7, p.31, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02055894
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation, Proceedings of the National Academy of Sciences of the United States of America, vol.114, pp.574-579, 2017. ,
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice, The Journal of experimental medicine, vol.213, pp.2635-2654, 2016. ,
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease, Cell reports, vol.9, pp.1135-1150, 2014. ,
Metastability of native proteins and the phenomenon of amyloid formation, J Am Chem Soc, vol.133, pp.14160-14163, 2011. ,
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex, The EMBO journal, vol.37, pp.282-299, 2018. ,
The spectrum of disease in chronic traumatic encephalopathy, Brain, vol.136, pp.43-64, 2013. ,
The common architecture of cross-beta amyloid, Journal of molecular biology, vol.395, pp.717-727, 2010. ,
Amyloid polymorphism: structural basis and neurobiological relevance, Neuron, vol.86, pp.632-645, 2015. ,
The amyloid state and its association with protein misfolding diseases, Nature reviews. Molecular cell biology, vol.15, pp.384-396, 2014. ,
How the shapes of seeds can influence pathology, Neurobiol Dis, vol.109, pp.201-208, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01571236
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases, 2019. ,
Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone, Journal of neuroscience research, vol.86, pp.2763-2773, 2008. ,
Cryo-EM structures of tau filaments from Alzheimer's disease, Nature, vol.547, pp.185-190, 2017. ,
Novel tau filament fold in corticobasal degeneration, Nature, vol.37, 2020. ,
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains, Cell, vol.180, pp.633-644, 2020. ,
Interaction of thioflavin T with amyloid fibrils: stoichiometry and affinity of dye binding, absorption spectra of bound dye, J Phys Chem B, vol.115, pp.11519-11524, 2011. ,
Investigation of alpha-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T, International journal of molecular sciences, p.19, 2018. ,
Inert and seedcompetent tau monomers suggest structural origins of aggregation, Annu Rev Neurosci, vol.40, pp.189-210, 2017. ,
The HSP110/HSP70 disaggregation system generates spreadingcompetent toxic ?-synuclein species, The EMBO journal, p.103954, 2020. ,
Human cyclophilin 40 unravels neurotoxic amyloids, PLoS biology, vol.15, p.2001336, 2017. ,
Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme, Cell reports, vol.26, pp.2140-2149, 2019. ,
Gene expression changes in the course of normal brain aging are sexually dimorphic, Proceedings of the National Academy of Sciences of the United States of America 105, pp.15605-15610, 2008. ,
Evolution of the aging brain transcriptome and synaptic regulation, PloS one, vol.3, p.3329, 2008. ,
Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons, Proceedings of the National Academy of Sciences of the United States of America, vol.105, pp.4441-4446, 2008. ,
Regional and cellular gene expression changes in human Huntington's disease brain, Human molecular genetics, vol.15, pp.965-977, 2006. ,
Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease, Neurogenetics, vol.7, pp.1-11, 2006. ,
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies, Acta Neuropathol Commun, vol.4, p.117, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01391925
Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle, Nat Struct Mol Biol, vol.20, pp.929-935, 2013. ,
ATPase-defective derivatives of Escherichia coli DnaK that behave differently with respect to ATP-induced conformational change and peptide release, J Bacteriol, vol.183, pp.5482-5490, 2001. ,
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation, The EMBO journal, vol.31, pp.4221-4235, 2012. ,
The ORFeome Collaboration: a genome-scale human ORF-clone resource, The Journal of biological chemistry, vol.283, pp.191-192, 2008. ,
Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis, Nature communications, vol.10, p.4851, 2019. ,
an open-source platform for biological-image analysis, Nat Methods, vol.9, pp.676-682, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02616466
, Quantification of cells containing TauP301S-Venus foci. n = 3 replicates with 288 -460 cells per condition in each replicate, mean ± SD. Statistical analysis was performed using a one-way ANOVA with Bonferroni's multiple comparison test, p.1