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Le projet TELEDOS : télé-service pour le calcul de dose en radiothérapie

Bénédicte Poumarède 1 Bouchra Habib 1 Jean-Marc Bordy 2 François Tola 3
1 LM2S - Laboratoire Modélisation et Simulation de Systèmes
DM2I - Département Métrologie Instrumentation & Information : DRT/LIST/DM2I
2 LNHB - Laboratoire National Henri Becquerel
DM2I - Département Métrologie Instrumentation & Information : DRT/LIST/DM2I
Abstract : These last years, the external radiotherapy evolved to an unceasingly increasing of the conformation with the irradiated volume in order to be able to increase the dose to the tumor without increasing toxicity in normal tissues around. This leads to an unceasingly increasing research of the treatment precision. The tools currently available, using conventional numerical methods are fast but not very accurate. An innovative solution is to use Monte Carlo statistical methods, able to give results close to reality, but with calculation times much longer. To meet this challenge, the TELEDOS project, grouping specialists in the field of radiation and computers, was launched in January 2006 for a period of three years. It aimed to improve the uncertainty on the calculated dose in a calculation time less than 10 minutes. These objectives have been achieved by establishing a fast Monte Carlo code on a dedicated parallel and secure architecture. As part of this development, the CEA LIST has been working on optimization, parallelization and dosimetric validation of the Monte Carlo code. The BULL company has developed the hardware and software infrastructure for tele-calculating. The integration of the Monte Carlo code in the Isogray TPS and its availablility to clinical centers have been executed by the DOSISOFT company. At last, the clinical validation of the final product was provided by the clinical centers partners of the project (Institut Gustave Roussy, Institut Curie, Centre Alexis Vautrin, Centre Antoine Laccassagne). Several algorithms of variance reduction were implemented into the PENELOPE code. These include bremsstrahlung splitting, Russian roulette coupled with splitting and circular splitting in the case of geometries with rotational symmetry. All of these methods have enabled to gain a minimum factor of 100 on the calculation time. The parallelization of the PENELOPE code and its optimized version PENFAST allowed to gain a time factor proportional to the number of parallel processors. At least, the dosimetric validation of the optimized code has ensured that simulation results are accurate within the statistical uncertainty.
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https://hal-cea.archives-ouvertes.fr/cea-02570315
Contributor : Marie-France Robbe <>
Submitted on : Tuesday, May 12, 2020 - 7:15:31 PM
Last modification on : Wednesday, May 13, 2020 - 9:26:15 AM

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  • HAL Id : cea-02570315, version 1

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Bénédicte Poumarède, Bouchra Habib, Jean-Marc Bordy, François Tola. Le projet TELEDOS : télé-service pour le calcul de dose en radiothérapie. 48èmes journées scientifiques de la Société Française de Physique Médicale (JS-SFPM - 2009), Société Française de Physique Médicale, Jun 2009, Montauban, France. ⟨cea-02570315⟩

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