Skip to Main content Skip to Navigation
Journal articles

Use of dissolved hyperpolarized species in NMR: practical considerations

Patrick Berthault 1 Céline Boutin 1 Charlotte Martineau-Corcos 2 Guillaume Carret 3 
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : Hyperpolarization techniques that can transiently boost nuclear spin polarization are generally carried out at low temperature-as in the case of dynamic nuclear polarization-or at high temperature in the gaseous state-as in the case of optically pumped noble gases. This review aims at describing the various issues and challenges that have been encountered during dissolution of hyperpolarized species, and solutions to these problems that have been or are currently proposed in the literature. During the transport of molecules from the polarizer to the NMR detection region, and when the hyperpolarized species or a precursor of hyperpolarization (e.g. parahydrogen) is introduced into the solution of interest, several obstacles need to be overcome to keep a high level of final magnetization. The choice of the magnetic field, the design of the dissolution setup, and ways to isolate hyperpolarized compounds from relaxation agents will be presented. Due to the non-equilibrium character of the hyperpolarization, new NMR pulse sequences that perform better than the classical ones will be described. Finally, three applications in the field of biology will be briefly mentioned.
Document type :
Journal articles
Complete list of metadata

Cited literature [135 references]  Display  Hide  Download
Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Wednesday, April 29, 2020 - 2:25:12 PM
Last modification on : Wednesday, September 28, 2022 - 5:49:17 AM


Files produced by the author(s)



Patrick Berthault, Céline Boutin, Charlotte Martineau-Corcos, Guillaume Carret. Use of dissolved hyperpolarized species in NMR: practical considerations. Progress in Nuclear Magnetic Resonance Spectroscopy, Elsevier, 2020, ⟨10.1016/j.pnmrs.2020.03.002⟩. ⟨cea-02558278⟩



Record views


Files downloads