Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue BMC Psychiatry Année : 2020

Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

Eesha Sharma
  • Fonction : Auteur
Bharath Holla
  • Fonction : Auteur
Meera Purushottam
  • Fonction : Auteur
Amit Chakrabarti
  • Fonction : Auteur
Kamakshi Kartik
  • Fonction : Auteur
Preeti Jacob
  • Fonction : Auteur
Madhavi Rangaswamy
  • Fonction : Auteur
Rose Dawn Bharath
  • Fonction : Auteur
Chirag Ahuja
  • Fonction : Auteur
Pratima Murthy
  • Fonction : Auteur
Sanjeev Jain
  • Fonction : Auteur
Mathew Varghese
  • Fonction : Auteur
Deepak Jayarajan
  • Fonction : Auteur
Keshav Kumar
  • Fonction : Auteur
Kandavel Thennarasu
  • Fonction : Auteur
Debashish Basu
  • Fonction : Auteur
B. Subodh
  • Fonction : Auteur
Rebecca Kuriyan
  • Fonction : Auteur
Sunita Simon Kurpad
  • Fonction : Auteur
Kumaran Kalyanram
  • Fonction : Auteur
Ghattu Krishnaveni
  • Fonction : Auteur
Murali C. Krishna
  • Fonction : Auteur
Rajkumar Lenin Singh
  • Fonction : Auteur
L. Roshan Singh
  • Fonction : Auteur
Vivek Benegal
  • Fonction : Auteur

Résumé

Background Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. Methods cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. Discussion The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns.
Fichier principal
Vignette du fichier
s12888-019-2373-3.pdf (1.16 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

cea-02555640 , version 1 (27-04-2020)

Identifiants

Citer

Eesha Sharma, Nilakshi Vaidya, Udita Iyengar, Yuning Zhang, Bharath Holla, et al.. Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol. BMC Psychiatry, 2020, 20 (1), ⟨10.1186/s12888-019-2373-3⟩. ⟨cea-02555640⟩
123 Consultations
100 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More