Thermosensitive and Mucoadhesive Pluronic-Hydroxypropylmethylcellulose Hydrogel Containing the Mini-CD4 M48U1 Is a Promising Efficient Barrier against HIV Diffusion through Macaque Cervicovaginal Mucus

Kawthar Bouchemal (1) , Armelle Aka-Any-Grah (1, 2) , Nathalie Dereuddre-Bosquet (3) , Loïc M Martin (4) , Vanessa Lievin-Le-Moal (5) , Roger Le Grand (3) , Valérie Nicolas (6) , Davide Gibellini (7) , David Lembo (8) , Christian Poüs (9) , Armand Koffi (2) , Gilles Ponchel (10)

1 IGPS - Institut Galien Paris-Sud
2 UFHB - Université Félix Houphouët-Boigny
3 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
4 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
5 BioCIS - Biomolécules : Conception, Isolement, Synthèse
6 IPSIT - Institut Paris Saclay d’Innovation Thérapeutique
7 UNIVR - Università degli studi di Verona = University of Verona
8 UNITO - Università degli studi di Torino = University of Turin
9 Innovation Thérapeutique : du Fondamental au Médicament
10 PCPB - Physico-chimie, pharmacotechnie, biopharmacie

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Biochemistry [q-bio.BM]; Life Sciences [q-bio]; Pharmaceutical sciences; Medication; Life Sciences [q-bio]; Pharmaceutical sciences; Galenic pharmacology

Kawthar Bouchemal, Armelle Aka-Any-Grah, Nathalie Dereuddre-Bosquet, Loïc M Martin, Vanessa Lievin-Le-Moal, et al.. Thermosensitive and Mucoadhesive Pluronic-Hydroxypropylmethylcellulose Hydrogel Containing the Mini-CD4 M48U1 Is a Promising Efficient Barrier against HIV Diffusion through Macaque Cervicovaginal Mucus. Antimicrobial Agents and Chemotherapy, 2015, 59 (4), pp.2215-2222. ⟨10.1128/AAC.03503-14⟩. ⟨cea-02530843⟩