MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

Nathalie Dereuddre-Bosquet (1) , Laurence Morellato-Castillo (2) , Joachim Brouwers , Patrick Augustijns (3) , Kawthar Bouchemal (4) , Gilles Ponchel (5) , Oscar Ramos (6) , Carolina Herrera , Martha Stefanidou , Robin J Shattock (7) , Leo Heyndrickx , Guido Vanham (8) , Pascal Kessler (2) , Roger Le Grand (1) , Loïc M Martin (2)

1 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
2 DRF (CEA) - Direction de Recherche Fondamentale (CEA)
3 Lab Pharmacotechnology and Biopharmacy
4 IGPS - Institut Galien Paris-Sud
5 PCPB - Physico-chimie, pharmacotechnie, biopharmacie
6 IAP - Institut d'Astrophysique de Paris
7 Imperial College London
8 Department of Microbiology

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Biochemistry [q-bio.BM]; Life Sciences [q-bio]; Immunology; Immunotherapy; Life Sciences [q-bio]; Pharmaceutical sciences; Medication

Nathalie Dereuddre-Bosquet, Laurence Morellato-Castillo, Joachim Brouwers, Patrick Augustijns, Kawthar Bouchemal, et al.. MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques. PLoS Pathogens, 2012, 8 (12), pp.e1003071. ⟨10.1371/journal.ppat.1003071⟩. ⟨cea-02530573⟩