MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

Katrijn Grupping , Philippe Selhorst (1) , Johan Michiels (2) , Katleen Vereecken , Leo Heyndrickx , Pascal Kessler (3) , Loïc M Martin (3) , Guido Vanham (1) , Kevin Ariën

1 Department of Microbiology
2 ITM - Institute of Tropical Medicine [Antwerp]
3 DRF (CEA) - Direction de Recherche Fondamentale (CEA)

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Biochemistry [q-bio.BM]; Life Sciences [q-bio]; Pharmaceutical sciences; Medication

Katrijn Grupping, Philippe Selhorst, Johan Michiels, Katleen Vereecken, Leo Heyndrickx, et al.. MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency. Retrovirology, 2012, 9 (1), pp.36. ⟨10.1186/1742-4690-9-36⟩. ⟨cea-02530546⟩