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Intact NMR spectroscopy: slow high-resolution magic angle spinning chemical shift imaging

Covadonga Lucas-Torres 1 Alan Wong 1
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : High-Resolution Magic-Angle Spinning Chemical Shift Imaging (HR-MAS CSI) has recently been explored for nuclear magnetic resonance (NMR) metabolomics and shows considerable promise in organism research. This is due to its ability to offer a supplemental dimension – spatial metabolic distribution – for profiling. However, HR-MAS CSI suffers from the large centrifugal stress exerted on the sample, which inevitably hinders the metabolic assessment. Herein, a slow sample spinning strategy was implemented and evaluated. The results demonstrate its potential as a highly informative profiling approach for intact specimens, with high quality data and feasibility.
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https://hal-cea.archives-ouvertes.fr/cea-02504285
Contributor : Serge Palacin <>
Submitted on : Tuesday, March 10, 2020 - 3:55:25 PM
Last modification on : Saturday, April 4, 2020 - 5:03:53 PM

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Covadonga Lucas-Torres, Alan Wong. Intact NMR spectroscopy: slow high-resolution magic angle spinning chemical shift imaging. Analyst, Royal Society of Chemistry, 2020, 145, pp.2520-2524. ⟨10.1039/D0AN00118J⟩. ⟨cea-02504285⟩

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