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NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines

Mégane Valero 1 Donia Bouzouita 2 Alberto Palazzolo 3 Jens Atzrodt 1 Christophe Dugave 3 Simon Tricard 2 Sophie Feuillastre 3 Grégory Pieters 3, * Bruno Chaudret 2 Volker Derdau 1
* Corresponding author
1 Sanofi-Aventis Deutschland GmbH
2 LPCNO - Laboratoire de physique et chimie des nano-objets
3 SCBM - Service de Chimie Bio-Organique et de Marquage
Abstract : The preparation of N-heterocyclic carbene-stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air-stable and easy-to-handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient hydrogen isotope incorporation on anilines using D-2 or T-2 as isotopic source. The usefulness of this transformation has been demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals.
Keywords : C-H activation C-H functionalization heterogeneous catalysis hydrogen isotope exchange iridium nanoparticles
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Journal articles
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https://hal-cea.archives-ouvertes.fr/cea-02490702
Contributor : Marianne Leriche <>
Submitted on : Tuesday, February 25, 2020 - 2:07:26 PM
Last modification on : Thursday, April 8, 2021 - 2:38:02 PM

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Mégane Valero, Donia Bouzouita, Alberto Palazzolo, Jens Atzrodt, Christophe Dugave, et al.. NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (9), pp.3517-3522. ⟨10.1002/anie.201914369⟩. ⟨cea-02490702⟩

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