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Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling

Abstract : A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-C-13/14] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.
Keywords : Spectrometry
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Malvika Sardana, Joakim Bergman, Cecilia Ericsson, Lee Kingston, Magnus Schou, et al.. Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling. Journal of Organic Chemistry, American Chemical Society, 2019, 84 (24), pp.16076-16085. ⟨10.1021/acs.joc.9b02575⟩. ⟨cea-02488945⟩

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