Skip to Main content Skip to Navigation

Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling of Complex Molecules Containing N-Heterocycles and Reaction Mechanism Insights

Abstract : Ruthenium nanocatalysis can provide effective deuteration and tritiation of oxazole, imidazole, triazole and carbazole substructures in complex molecules using D2 or T2 gas as isotopic sources. Depending on the substructure considered, this approach does not only represent a significant step forward in practice, with notably higher isotope uptakes, a broader substrate scope and a higher solvent applicability compared to existing procedures, but also the unique way to label important heterocycles using hydrogen isotope exchange. In terms of applications, the high incorporation of deuterium atoms, allows the synthesis of internal standards for LC-MS quantification. Moreover, the efficacy of the catalyst permits, even under subatmospheric pressure of T2 gas, the preparation of complex radiolabeled drugs owning high molar activities. From a fundamental point of view, a detailed DFT-based mechanistic study identifying undisclosed key intermediates, allowed a deeper understanding of C-H (and N-H) activation processes occurring at the surface of metallic nanoclusters.
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://hal-cea.archives-ouvertes.fr/cea-02487414
Contributor : Sophie Feuillastre <>
Submitted on : Friday, February 21, 2020 - 3:41:58 PM
Last modification on : Tuesday, March 3, 2020 - 11:40:04 AM

File

Pieters_et_al-2020-Chemistry_-...
Files produced by the author(s)

Identifiers

Citation

Viktor Pfeifer, Marie Certiat, Donia Bouzouita, Alberto Palazzolo, Sébastien Garcia-Argote, et al.. Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling of Complex Molecules Containing N-Heterocycles and Reaction Mechanism Insights. Chemistry - A European Journal, Wiley-VCH Verlag, 2019, ⟨10.1002/chem.201905651⟩. ⟨cea-02487414⟩

Share

Metrics

Record views

33

Files downloads

65