B. Albert and C. H. Sellem, Dynamics of the mitochondrial genome during Podospora anserina aging, Curr. Genet, vol.40, pp.365-373, 2002.

N. ?-altamura, N. Capitanio, N. Bonnefoy, S. Papa, and G. Dujardin, The Saccharomyces cerevisiae OXA1 gene is required for the correct assembly of cytochrome c oxidase and oligomycin-sensitive ATP synthase, FEBS Lett, vol.382, pp.111-115, 1996.

C. Barreau, C. Sellem, P. Silar, A. Sainsard-chanet, and B. Turcq, A rapid and efficient method using chromoslots to assign any newly cloned DNA sequence to its cognate chromosome in the filamentous fungus Podospora anserina, FEMS Microbiol. Lett, vol.216, pp.55-60, 2002.

M. Bauer, M. Behrens, K. Esser, G. Michaelis, and E. Pratje, PET1402, a nuclear gene required for proteolytic processing of cytochrome oxidase subunit 2 in yeast, Mol. Gen. Genet, vol.245, pp.272-278, 1994.

L. Belcour, O. Begel, and M. Picard, A site-specific deletion in mitochondrial DNA of Podospora is under the control of nuclear genes, Proc. Natl. Acad. Sci. USA, vol.88, pp.3579-3583, 1991.

L. Belcour, A. Sainsard-chanet, C. Jamet-vierny, and M. Picard, Heat shock at an elevated temperature improves transformation efficiency of protoplasts from Podospora anserina, J. Gen. Microbiol, vol.135, pp.601-604, 1989.

N. Bonnefoy, F. Chalvet, P. Hamel, P. P. Slonimski, and G. Dujardin, OXA1, a Saccharomyces cerevisiae nuclear gene whose sequence is conserved from prokaryotes to eukaryotes controls cytochrome oxidase biogenesis, J. Mol. Biol, vol.239, pp.201-212, 1994.

N. Bonnefoy, M. Kermorgant, O. Groudinsky, M. Minet, and P. P. Slonimski, Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1-mutation in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci, vol.91, pp.11978-11982, 1994.

N. Bonnefoy, M. Kermorgant, O. Groudinsky, and G. Dujardin, The respiratory gene OXA1 has two fission yeast orthologues which together encode a function essential for cellular viability, Mol. Microbiol, vol.35, pp.1135-1145, 2000.

C. Borghouts, A. Werner, T. Elthon, and H. D. Osiewacz, Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina, Mol. Cell. Biol, vol.21, pp.390-399, 2001.

C. Borghouts, C. Q. Scheckhuber, A. Werner, and H. D. Osiewacz, Respiration, copper availability and SOD activity in P. anserina strains with different life span, Biogerontology, vol.3, pp.143-153, 2002.

A. C. Bryan, M. S. Rodeheffer, C. M. Wearn, and G. S. Shadel, Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression, Genetics, vol.160, pp.75-82, 2002.

V. ?-contamine, G. Lecellier, L. Belcour, and M. Picard, Premature death in Podospora anserina: sporadic accumulation of the deleted mitochondrial genome, translational parameters and innocuity of the mating types, Genetics, vol.144, pp.541-555, 1996.

V. ?-contamine, D. Zickler, and M. Picard, The Podospora rmp1 gene implicated in nucleus-mitochondria cross-talk encodes an essential protein whose subcellular location is developmentally regulated, Genetics, vol.166, pp.135-150, 2004.

E. ?-coppin and R. Debuchy, Co-expression of the mating-type genes involved in internuclear recognition is lethal in Podospora anserina, Genetics, vol.155, pp.657-669, 2000.

R. Debuchy, S. Arnaise, and G. Lecellier, The mat-allele of Podospora anserina contains three regulatory genes required for the development of fertilized female organs, Mol. Gen. Genet, vol.241, pp.667-673, 1993.

C. ?-d'enfert, M. Minet, and F. Lacroute, Cloning plant genes by complementation of yeast mutants, Methods Cell Biol, vol.49, pp.417-430, 1995.

?. Dequard-chablat, M. , and C. H. Sellem, The S12 ribosomal protein of Podospora anserina belongs to the S19 bacterial family and controls the mitochondrial genome integrity through cytoplasmic translation, J. Biol. Chem, vol.269, pp.14951-14956, 1994.

?. Dequard-chablat, M. , E. Coppin-raynal, M. Picard-bennoun, and J. J. Madjar, At least seven ribosomal proteins are involved in the control of translational accuracy in a eukaryotic organism, J. Mol. Biol, vol.190, pp.167-175, 1986.

A. ?-dillin, A. L. Hsu, N. Arantes-oliveira, J. Lehrer-graiwer, and H. Hsin, Rates of behavior and aging specified by mitochondrial function during development, Science, vol.298, pp.2398-2401, 2002.

E. Dufour, J. Boulay, V. Rincheval, and A. Sainsard-chanet, A causal link between respiration and senescence in Podospora anserina, Proc. Natl. Acad. Sci. USA, vol.97, pp.4138-4143, 2000.

T. ?-elthon, R. L. Nickels, and L. Mcintosh, Monoclonal antibodies to the alternative oxidase of higher plants mitochondria, Plant Physiol, vol.89, pp.1311-1317, 1989.

K. Esser, Podospora anserina, in Handbook of Genetics, pp.531-551, 1974.

J. Feng, F. Bussiere, and S. Hekimi, Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans, Dev. Cell, vol.1, pp.633-644, 2001.

P. Hamel, W. Sakamoto, H. Wintz, and G. Dujardin, Functional complementation of an oxa1-yeast mutation identifies an Arabidopsis thaliana cDNA involved in the assembly of respiratory complexes, Plant J, vol.12, pp.1319-1327, 1997.

P. Hamel, C. Lemaire, N. Bonnefoy, P. Brivet-chevillotte, and G. Dujardin, Mutations in the membrane anchor of yeast cytochrome c1 compensate for the absence of Oxa1p and generate carbonate-extractable forms of cytochrome c1, Genetics, vol.150, pp.601-611, 1998.

D. Harman, Aging: a theory based on free radical and radiation chemistry, J. Gerontol, vol.11, pp.298-300, 1956.

P. Harman, Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans, Mech. Ageing Dev, vol.122, pp.1187-1201, 2001.

J. M. Herrmann and W. Neupert, Protein insertion into the inner membrane of mitochondria, IUBMB Life, vol.55, pp.219-225, 2003.

N. Ishii, M. Fujii, P. S. Hartman, M. Tsuda, and K. Yasuda, A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes, Nature, vol.394, pp.694-697, 1998.

L. Jia, M. Dienhart, M. Schramp, M. Mccauley, and K. Hell, Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1, EMBO J, vol.22, pp.6438-6447, 2003.

A. Kuhn, R. Stuart, R. Henry, and R. E. Dalbey, The Alb3/Oxa1/YidC protein family: Membrane-localized chaperones facilitating membrane protein insertion?, Trends Cell Biol, vol.13, pp.510-516, 2003.

S. S. Lee, R. Y. Lee, A. G. Fraser, R. S. Kamath, and J. Ahringer, A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity, Nat. Genet, vol.33, pp.40-48, 2003.

S. ?-lorin, E. Dufour, J. Boulay, O. Begel, and S. Marsy, Overexpression of the alternative oxidase restores senescence and fertility in a long-lived respiration-deficient mutant of Podospora anserina, Mol. Microbiol, vol.42, pp.1259-1267, 2001.

H. R. Mclennan and M. Degli-esposti, The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species, J. Bioenerg. Biomembr, vol.32, pp.153-162, 2000.

W. Meyer, M. Bauer, and E. Pratje, A mutation in cytochrome oxidase subunit 2 restores respiration of the mutant pet ts1402, Curr. Genet, vol.31, pp.401-407, 1997.

W. Meyer, U. Bomer, and E. Pratje, b Mitochondrial inner membrane bound Pet1402 protein is rapidly imported into mitochondria and affects the integrity of the cytochrome oxidase and ubiquinol-cytochrome c oxidoreductase complexes, Biol. Chem, vol.378, pp.1373-1379, 1997.

K. Munkres, Histochemical detection of superoxide radicals and hydrogen peroxide by Age-1 mutants of Neurospora, Fungal Genet. Newsl, vol.37, pp.24-25, 1990.

F. E. Nargang, M. Preuss, W. Neupert, and J. M. Herrmann, The Oxa1 protein forms a homooligomeric complex and is an essential part of the mitochondrial export translocase in Neurospora crassa, J. Biol. Chem, vol.277, pp.12846-12853, 2002.

L. G. Nijtmans, N. S. Henderson, and I. J. Holt, Blue Native electrophoresis to study mitochondrial and other protein complexes, Methods, vol.26, pp.327-334, 2002.

G. Rizet, Les phénomènes de barrage chez Podospora anserina. I. Analyse génétique des barrages entre souches S et s, Rev. Cytol. Biol. Vég, vol.13, pp.51-92, 1952.

G. Rizet, Impossibility of obtaining uninterrupted and unlimited multiplication of the ascomycete Podospora anserina, C. R. Hebd. Seances Acad. Sci, vol.237, pp.838-840, 1953.

G. Rizet and C. Engelmann, Contribution à l'étude génétique d'un ascomycète tetraspore, Podospora. Rev. Cytol. Biol. Vég, vol.11, pp.201-304, 1949.

M. S. Rodeheffer and G. S. Shadel, Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis, J. Biol. Chem, vol.278, pp.18695-18701, 2003.

J. M. ?-rouillard, M. E. Dufour, B. Theunissen, E. Mandart, and G. Dujardin, SLS1, a new Saccharomyces cerevisiae gene involved in mitochondrial metabolism, isolated as a synthetic lethal in association with an SSM4 deletion, Mol. Gen. Genet, vol.252, pp.700-708, 1996.

H. Schagger and G. Von-jagow, Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form, Anal. Biochem, vol.199, pp.223-231, 1991.

C. H. Sellem, A. Sainsard-chanet, and L. Belcour, Detection of a protein encoded by a class II mitochondrial intron of Podospora anserina, Mol. Gen. Genet, vol.224, pp.232-240, 1990.

M. K. Shigenaga, T. M. Hagen, and B. N. Ames, Oxidative damage and mitochondrial decay in aging, Proc. Natl. Acad. Sci, vol.91, pp.10771-10778, 1994.

P. Silar, Two new easy to use vectors for transformation, Fungal Genet. Newsl, vol.42, p.73, 1995.

F. E. Sluse and W. Jarmuszkiewicz, Alternative oxidase in the branched mitochondrial respiratory network: an overview on structure, function, regulation, and role. Braz, J. Med. Biol. Res, vol.31, pp.733-747, 1998.

S. W. Stumpferl, O. Stephan, and H. D. Osiewacz, Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span, Eukaryot. Cell, vol.3, pp.200-211, 2004.

G. Szyrach, M. Ott, N. Bonnefoy, W. Neupert, and J. M. Herrmann, Ribosome binding to the Oxa1 complex facilitates co-translational protein insertion in mitochondria, EMBO J, vol.22, pp.6448-6457, 2003.

A. Trifunovic, A. Wredenberg, M. Falkenberg, J. N. Spelbrink, and A. T. Rovio, Premature ageing in mice expressing defective mitochondrial DNA polymerase, Nature, vol.429, pp.417-423, 2004.

B. Turcq, Clonage direct de gènes par complementation chez le champignon Podospora anserina: application à l'étude de gènes d'incompatibilité, 1989.

G. C. Vanlerberghe and L. Mcintosh, Alternative oxidase: from gene to function, Annu. Rev. Plant Physiol. Plant Mol. Biol, vol.48, pp.703-734, 1997.

A. M. Wagner, A role for active oxygen species as second messengers in the induction of alternative oxidase gene expression in Petunia hybrida cells, FEBS Lett, vol.368, pp.339-342, 1995.

H. Yukioka, S. Inagaki, R. Tanaka, K. Katoh, and N. Miki, Transcriptional activation of the alternative oxidase gene of the fungus Magnaporthe grisea by a respiratory-inhibiting fungicide and hydrogen peroxide, Biochim. Biophys. Acta, vol.1442, pp.161-169, 1998.