a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol, vol.25, pp.7459-7469, 2007. ,
A pilot clinical trial of a recombinant ricin vaccine in normal humans, Proc. Natl. Acad. Sci, vol.103, pp.2268-2273, 2006. ,
Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo, Hybridoma, vol.13, pp.417-421, 1994. ,
Neutralising antibodies against ricin toxin, PLoS One, vol.6, 2011. ,
Transition state analogues for enzymes of nucleic acid metabolism, Nucleic Acids Res. Suppl, pp.107-108, 2003. ,
The X-ray structure of ricin A chain with a novel inhibitor, Arch. Biochem. Biophys, vol.483, pp.23-28, 2009. ,
Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition, J. Med. Chem, vol.45, pp.90-98, 2002. ,
Structure-based identification of a ricin inhibitor, J. Mol. Biol, vol.266, pp.1043-1049, 1997. ,
Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design, J. Am. Chem. Soc, vol.129, pp.5544-5550, 2007. ,
Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity, World J. Gastroenterol, vol.14, pp.6360-6365, 2008. ,
In vitro selection of RNA molecules that inhibit the activity of ricin A-chain, J. Biol. Chem, vol.275, pp.4937-4942, 2000. ,
Structural analysis of ricin and implications for inhibitor design, Toxicon, vol.34, pp.1325-1334, 1996. ,
Identification of new classes of ricin toxin inhibitors by virtual screening, Toxicon, vol.56, pp.526-534, 2011. ,
Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen, Toxicon, vol.56, pp.313-323, 2010. ,
Inhibition of retrograde transport protects mice from lethal ricin challenge, Cell, vol.141, pp.231-242, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00509058
Identification and characterization of small molecules that inhibit intracellular toxin transport, Infect. Immun, vol.75, pp.4552-4561, 2007. ,
Tracing the retrograde route in protein trafficking, Cell, vol.135, pp.1175-1187, 2008. ,
Toxin entry and trafficking in mammalian cells, Adv. Drug Deliv. Rev, vol.58, pp.1581-1596, 2006. ,
Pathways followed by protein toxins into cells, Int. J. Med. Microbiol, vol.293, pp.483-490, 2004. ,
Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: Co-opting basic mechanisms of endoplasmic reticulum-associated degradation, Curr. Top. Microbiol. Immunol, vol.300, pp.149-168, 2005. ,
A quantitative and highly sensitive luciferase-based assay for bacterial toxins that inhibit protein synthesis, J. Med. Microbiol, vol.54, pp.1023-1030, 2005. ,
Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells, Exp. Cell Res, vol.219, pp.671-678, 1995. ,
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, vol.73, pp.1079-1090, 1993. ,
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway, Eur. J. Pharmacol, vol.556, pp.45-54, 2007. ,
Interactions of (-)-ilimaquinone with methylation enzymes: Implications for vesicular-mediated secretion, Chem. Biol, vol.6, pp.639-647, 1999. ,
Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin, Exp. Cell Res, vol.192, pp.389-395, 1991. ,
Drugs that show protective effects from ricin toxicity in in vitro protein synthesis assays, Nat. Toxins, vol.3, pp.369-377, 1995. ,
Inhibition of Shiga-like toxins by brefeldin A, J. Infect. Dis, vol.171, pp.721-724, 1995. ,
Brefeldin A: Insights into the control of membrane traffic and organelle structure, J. Cell Biol, vol.116, pp.1071-1080, 1992. ,
Ricin transport in brefeldin A-treated cells: Correlation between Golgi structure and toxic effect, J. Cell Biol, vol.115, pp.971-981, 1991. ,
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein, Nature, vol.360, pp.350-352, 1992. ,
Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: Involvement of specific residues of the Sec7 domain, Mol. Cell, vol.3, pp.275-285, 1999. ,
Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism, Mol. Cell, vol.12, pp.1403-1411, 2003. ,
Localization and function of Arf family GTPases, Biochem. Soc. Trans, vol.33, pp.639-642, 2005. ,
Multiple activities for Arf1 at the Golgi complex, Biochim. Biophys. Acta, vol.1744, pp.364-373, 2005. ,
The mechanisms of vesicle budding and fusion, Cell, vol.116, pp.153-166, 2004. ,
Adaptable adaptors for coated vesicles, Trends Cell Biol, vol.14, pp.167-174, 2004. ,
Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi, Mol. Biol. Cell, vol.16, pp.1213-1222, 2005. ,
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function, Nat. Chem. Biol, vol.5, pp.157-165, 2009. ,
Exo1: A new chemical inhibitor of the exocytic pathway, Proc. Natl. Acad. Sci, vol.100, pp.6469-6474, 2003. ,
Phenotypic screening of small molecule libraries by high throughput cell imaging, Comb. Chem. High. Throughput Screen, vol.6, pp.279-286, 2003. ,
Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells, EMBO Rep, vol.5, pp.596-601, 2004. ,
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network, Biochem. J, vol.414, pp.471-484, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00478957
LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells, Traffic, vol.11, pp.1537-1551, 2010. ,
Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells, Mol. Biosyst, vol.6, pp.2030-2038, 2010. ,
Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking, Eur. J. Med. Chem, vol.45, pp.275-283, 2010. ,
Shiga toxin B-subunit as a tool to study retrograde transport, Methods Mol. Med, vol.73, pp.209-220, 2003. ,
Identifying the proteins to which small-molecule probes and drugs bind in cells, Proc. Natl. Acad. Sci, vol.106, pp.4617-4622, 2009. ,
Chemical dimerizers and three-hybrid systems: Scanning the proteome for targets of organic small molecules, Chem. Biol, vol.11, pp.599-608, 2004. ,
A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors, Chem. Biol, vol.11, pp.211-223, 2004. ,
Identification of direct protein targets of small molecules, ACS Chem. Biol, vol.6, pp.34-46, 2011. ,
Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors, Proc. Natl. Acad. Sci, vol.97, pp.2419-2424, 2000. ,
Systems-based design of bi-ligand inhibitors of oxidoreductases: Filling the chemical proteomic toolbox, Chem. Biol, vol.11, pp.185-194, 2004. ,
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv. Drug Deliv. Rev, vol.46, pp.3-26, 2001. ,