Inhibitors of the Cellular Trafficking of Ricin - Archive ouverte HAL Access content directly
Journal Articles Toxins Year : 2012

Inhibitors of the Cellular Trafficking of Ricin

(1) , (1) , (2) , (1)
1
2

Abstract

Throughout the last decade, efforts to identify and develop effective inhibitors of the ricin toxin have focused on targeting its N-glycosidase activity. Alternatively, molecules disrupting intracellular trafficking have been shown to block ricin toxicity. Several research teams have recently developed high-throughput phenotypic screens for small molecules acting on the intracellular targets required for entry of ricin into cells. These screens have identified inhibitory compounds that can protect cells, and sometimes even animals against ricin. We review these newly discovered cellular inhibitors of ricin intoxication, discuss the advantages and drawbacks of chemical-genetics approaches, and address the issues to be resolved so that the therapeutic development of these small-molecule compounds can progress.
Fichier principal
Vignette du fichier
O8. toxins-04-00015.pdf (655.63 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

cea-02432365 , version 1 (08-01-2020)

Identifiers

Cite

Julien Barbier, Céline Bouclier, Ludger Johannes, Daniel Gillet. Inhibitors of the Cellular Trafficking of Ricin. Toxins, 2012, 4, pp.15-27. ⟨10.3390/toxins4010015⟩. ⟨cea-02432365⟩
155 View
61 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More