Skip to Main content Skip to Navigation
Journal articles

Inhibitors of the Cellular Trafficking of Ricin

Abstract : Throughout the last decade, efforts to identify and develop effective inhibitors of the ricin toxin have focused on targeting its N-glycosidase activity. Alternatively, molecules disrupting intracellular trafficking have been shown to block ricin toxicity. Several research teams have recently developed high-throughput phenotypic screens for small molecules acting on the intracellular targets required for entry of ricin into cells. These screens have identified inhibitory compounds that can protect cells, and sometimes even animals against ricin. We review these newly discovered cellular inhibitors of ricin intoxication, discuss the advantages and drawbacks of chemical-genetics approaches, and address the issues to be resolved so that the therapeutic development of these small-molecule compounds can progress.
Complete list of metadata

Cited literature [54 references]  Display  Hide  Download
Contributor : Julien Barbier Connect in order to contact the contributor
Submitted on : Wednesday, January 8, 2020 - 1:19:13 PM
Last modification on : Monday, December 13, 2021 - 9:15:17 AM
Long-term archiving on: : Thursday, April 9, 2020 - 6:17:07 PM


O8. toxins-04-00015.pdf
Files produced by the author(s)



Julien Barbier, Céline Bouclier, Ludger Johannes, Daniel Gillet. Inhibitors of the Cellular Trafficking of Ricin. Toxins, MDPI, 2012, 4, pp.15-27. ⟨10.3390/toxins4010015⟩. ⟨cea-02432365⟩



Record views


Files downloads