Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate

Romain Goulay , Julien Flament (1) , Maxime Gauberti (2) , Michael Naveau , Nolwenn Pasquet , Clement Gakuba , Evelyne Emery (2) , Philippe Hantraye (3) , Denis Vivien (2) , Romina Aron-Badin (4) , Thomas Gaberel (5)

1 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
2 Sérine protéases et physiopathologie de l'unité neurovasculaire
3 MIRCEN - Service MIRCEN
4 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
5 Hôpital Côte de Nacre [CHU Caen]

Subarachnoid hemorrhage (SAH) is a devastating form of stroke with neurological outcomes dependent on the occurrence of delayed cerebral ischemia. It has been shown in rodents that some of the mechanisms leading to delayed cerebral ischemia are related to a decreased circulation of the cerebrospinal fluid (CSF) within the brain parenchyma. Here, we evaluated the cerebral circulation of the CSF in a nonhuman primate in physiological condition and after SAH.

Keywords: brain; cerebral infarction; cerebrospinal fluid; homeostasis; subarachnoid hemorrhage

Domains: Life Sciences [q-bio]

Romain Goulay, Julien Flament, Maxime Gauberti, Michael Naveau, Nolwenn Pasquet, et al.. Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate. Stroke, 2017, 48 (8), pp.2301-2305. ⟨10.1161/STROKEAHA.117.017014⟩. ⟨cea-02397818⟩