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A new paradigm for high-sensitivity 19 F magnetic resonance imaging of perfluorooctylbromide

Abstract : In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high-sensitivity fluorine MRI strategy. It is shown that the harmful effects of J-coupling can be eliminated by carefully choosing the bandwidth of the 180 degrees pulses in a spin-echo sequence. The T(2) of the CF(3) resonance of the molecule is measured using a multispin-echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin-echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin-echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles.
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https://hal-cea.archives-ouvertes.fr/cea-02397769
Contributor : Julien Flament <>
Submitted on : Friday, December 6, 2019 - 4:40:19 PM
Last modification on : Saturday, September 26, 2020 - 11:44:05 PM

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Céline Giraudeau, Julien Flament, Benjamin Marty, Fawzi Boumezbeur, Sébastien Mériaux, et al.. A new paradigm for high-sensitivity 19 F magnetic resonance imaging of perfluorooctylbromide. Magnetic Resonance in Medicine, Wiley, 2010, 63 (4), pp.1119-1124. ⟨10.1002/mrm.22269⟩. ⟨cea-02397769⟩

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