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Journal articles
A new paradigm for high-sensitivity 19 F magnetic resonance imaging of perfluorooctylbromide
Céline Giraudeau
1
Julien Flament
1
Benjamin Marty
1
Fawzi Boumezbeur
2
Sébastien Mériaux
3
Caroline Robic
4
Marc Port
5
Nicolas Tsapis
6
Elias Fattal
7
Eric Giacomini
2
Franck Lethimonnier
1
Denis Le Bihan
2
Julien Valette
1
Sébastien Mériaux 3
Author
Caroline Robic 4
Author
Marc Port 5
Author
Nicolas Tsapis 6
Author IdHAL : nicolas-tsapis ORCID : https://orcid.org/0000-0003-2095-2626
Julien Valette 1
Author
1
LRMN - Laboratoire d'Imagerie et de Spectroscopie (France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DSV/I2BM/NEUROSPIN (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
2
NEUROSPIN - Service NEUROSPIN (France)
- DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JOLIOT (Direction de Recherche Fondamentale
Fundamental Research Division
CEA Saclay
91191 Gif-sur-Yvette
- France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
3
SHFJ - Service Hospitalier Frédéric Joliot (France)
- DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JOLIOT (Direction de Recherche Fondamentale
Fundamental Research Division
CEA Saclay
91191 Gif-sur-Yvette
- France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
4
LI2C - Liquides Ioniques et Interfaces Chargées (Bât. F-74 - Boîte 51 4 Place Jussieu 75252 PARIS CEDEX 05 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7612 (France)
- ESPCI ParisTech (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
5
Laboratoire Guerbet (Aulnay-Sous-Bois, France - France)
6
IGPS - Institut Galien Paris-Sud (Faculté de Pharmacie - Chatenay Malabry 5 Rue J.B Clément 92296 CHATENAY MALABRY CEDEX - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8612 (France)
7
PCPB - Physico-chimie, pharmacotechnie, biopharmacie (5 Rue J.B Clément 92296 CHATENAY MALABRY CEDEX - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8612 (France)
Abstract : In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high-sensitivity fluorine MRI strategy. It is shown that the harmful effects of J-coupling can be eliminated by carefully choosing the bandwidth of the 180 degrees pulses in a spin-echo sequence. The T(2) of the CF(3) resonance of the molecule is measured using a multispin-echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin-echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin-echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles.
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Journal articles
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https://hal-cea.archives-ouvertes.fr/cea-02397769
Contributor : Julien Flament <>
Submitted on : Friday, December 6, 2019 - 4:40:19 PM
Last modification on : Saturday, September 19, 2020 - 3:45:14 AM
Contributor : Julien Flament <>
Submitted on : Friday, December 6, 2019 - 4:40:19 PM
Last modification on : Saturday, September 19, 2020 - 3:45:14 AM
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- HAL Id : cea-02397769, version 1
- DOI : 10.1002/mrm.22269
- PUBMED : 20373415
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Citation
Céline Giraudeau, Julien Flament, Benjamin Marty, Fawzi Boumezbeur, Sébastien Mériaux, et al.. A new paradigm for high-sensitivity 19 F magnetic resonance imaging of perfluorooctylbromide. Magnetic Resonance in Medicine, Wiley, 2010, 63 (4), pp.1119-1124. ⟨10.1002/mrm.22269⟩. ⟨cea-02397769⟩
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