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Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

Che Serguera 1 Lev Stimmer 2 Claire-Maëlle Fovet 2 Philippe Horellou 3 Vanessa Contreras 4 Nicolas Tchitchek 5 Julie Massonneau 2 Carole Leroy 6 Audrey Perrin 5 Julien Flament 7 Philippe Hantraye 8 Joanna Demilly Romain Marignier 9 Pascale Chrétien Bert'T Hart Jean Boutonnat 10 Clovis Adam 11 Roger Le-Grand Kumaran Deiva 5 Bert‘t Hart 
1 Modélisation des biothérapies
2 MIRCEN - Service MIRCEN
3 Immunologie antivirale systémique et cérébrale
4 VIM (UR 0892) - Unité de recherche Virologie et Immunologie Moléculaires
5 IDMIT - Infectious Diseases Models for Innovative Therapies
6 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
7 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
8 I2BM - Institut d'Imagerie BioMédicale
9 Pierre Wertheimer
10 TIMC-IMAG-TheREx - Thérapeutique Recombinante Expérimentale
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
11 Service d'Anatomie Pathologique
Abstract : Autoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating syndromes (ADS) and physiopathology is still under investigation. As cynomolgus macaques immunized with rhMOG, all develop an experimental autoimmune encephalomyelitis (EAE), we assessed relatedness between anti-MOG-Abs associated diseases in both species.
Keywords : Cytokines Complement Brain inflammation Anti-MOG IgG CSF Demyelination
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https://hal-cea.archives-ouvertes.fr/cea-02397764
Contributor : Julien Flament Connect in order to contact the contributor
Submitted on : Friday, December 6, 2019 - 4:38:06 PM
Last modification on : Sunday, June 26, 2022 - 2:44:27 AM

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INSERM | CEA | UGA | IMAG | CNRS | INRA | TIMC-IMAG | TIMC-IMAG-THEREX | CEA-UPSAY | UNIV-PARIS-SACLAY | JACOB | CEA-DRF | MIRCEN | INRAE | GS-HEALTH-DRUG-SCIENCES

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Che Serguera, Lev Stimmer, Claire-Maëlle Fovet, Philippe Horellou, Vanessa Contreras, et al.. Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases. Journal of Neuroinflammation, BioMed Central, 2019, 16 (1), pp.244. ⟨10.1186/s12974-019-1637-7⟩. ⟨cea-02397764⟩

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