Formulation of stimulable multiple emulsions by microfluidics

Noémie Bodin (1, 2) , Marine Protat (1, 3) , Florent Malloggi (1) , Véronique Rosilio (2) , Patrick P. Guenoun (1) , Nadège Pantoustier (3) , Patrick Perrin (3)

1 LIONS - Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire
2 IGPS - Institut Galien Paris-Sud
3 SIMM - Sciences et Ingénierie de la Matière Molle (UMR 7615)

Multiple emulsions, in particular water-in-oil-in-water (w/o/w) emulsions, are promising systems for encapsulation and controIled delivery of drugs. We developed a new emulsifier, a poly(dimethylsiloxane)-b-poly(dimethylaminoethylmethacrylate) (PDMS-b-PDMAEMA) amphiphilic copolymer, capable of stabilizing multiple emulsions in one mixing step over long times. This polymer is stimuli responsive, aIlowing the formation of direct, inverse and w/o/w emulsions depending on the pH and ionic strength. It is then possible to consider the controIled release of a compound encapsulated in the inner water droplets. However it is highly desirable to both form monodisperse emulsions for reaching a reliable control of the delivery and differentiate the inner water phases carrying the cargo from the external water phase for avoiding tediol}s washing steps. For aIl these reasons microfluidics was considered as a promising tool and is shown here to provide first promising results.

Domaines: Matériaux

Noémie Bodin, Marine Protat, Florent Malloggi, Véronique Rosilio, Patrick P. Guenoun, et al.. Formulation of stimulable multiple emulsions by microfluidics. BiPoCo 2016, Aug 2016, Szeged, Hungary. ⟨cea-02351547⟩