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Formulation of stimulable multiple emulsions by microfluidics

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Abstract

Multiple emulsions, in particular water-in-oil-in-water (w/o/w) emulsions, are promising systems for encapsulation and controIled delivery of drugs. We developed a new emulsifier, a poly(dimethylsiloxane)-b-poly(dimethylaminoethylmethacrylate) (PDMS-b-PDMAEMA) amphiphilic copolymer, capable of stabilizing multiple emulsions in one mixing step over long times. This polymer is stimuli responsive, aIlowing the formation of direct, inverse and w/o/w emulsions depending on the pH and ionic strength. It is then possible to consider the controIled release of a compound encapsulated in the inner water droplets. However it is highly desirable to both form monodisperse emulsions for reaching a reliable control of the delivery and differentiate the inner water phases carrying the cargo from the external water phase for avoiding tediol}s washing steps. For aIl these reasons microfluidics was considered as a promising tool and is shown here to provide first promising results.
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Dates and versions

cea-02351547 , version 1 (06-11-2019)

Identifiers

  • HAL Id : cea-02351547 , version 1

Cite

Noémie Bodin, Marine Protat, Florent Malloggi, Véronique Rosilio, Patrick P. Guenoun, et al.. Formulation of stimulable multiple emulsions by microfluidics. BiPoCo 2016, Aug 2016, Szeged, Hungary. ⟨cea-02351547⟩
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