Accurate determination of pH via hyperpolarized $^{129}$Xe NMR

Estelle Léonce (1) , Thierry Brotin (2) , Jean-Pierre Dognon (1) , Patrick Berthault (1)

1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
2 LC - Laboratoire de Chimie - UMR5182

Measuring non-invasively and in a local way the in vivo extra-cellular pH is of importance for the diagnosis of insidious pathologies such as various cancers. For one decade, the use of hyperpolarized agents has been proposed; each method possesses its own advantage and inconvenience, and their applicability in the in vivo domain is not always straightforward. For instance,~ome years ago, we proposed the use of cage-molecules, bearing ionizable groups, in which laser-polarized xenon exhibits a pH-dependent chemical shift.' However extracting pH from measurement of the absolute chemical shift of caged xenon or even of the chemical shift difference between free and caged xenon is susceptible to be biased by external parameters such as temperature and magnetic susceptibility fluctuation.

Domaines: Matériaux

Estelle Léonce, Thierry Brotin, Jean-Pierre Dognon, Patrick Berthault. Accurate determination of pH via hyperpolarized $^{129}$Xe NMR. 39th FGMR Annual Discussion Meeting, Sep 2017, Bayreuth, Germany. ⟨cea-02341010⟩