Iron-Catalyzed Cross-Coupling of Functionalized Benzylmanganese Halides with Alkenyl Iodides, Bromides, and Triflates - Archive ouverte HAL Access content directly
Journal Articles Organic Letters Year : 2019

Iron-Catalyzed Cross-Coupling of Functionalized Benzylmanganese Halides with Alkenyl Iodides, Bromides, and Triflates

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Abstract

Various substituted benzylic manganese chlorides were prepared by insertion of magnesium turnings in the presence of MnCl2·2LiCl in THF at −5 °C within 2 h. These benzylic manganese reagents underwent smooth cross-couplings with various functionalized alkenyl iodides, bromides, and triflates or iodoacrylates in the presence of 10 mol % FeCl2 at 25 °C for 1–12 h. Mechanistic studies showed that benzylic manganese halides produced, in the presence of FeCl2, a very reactive iron ate complex.
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cea-02321208 , version 1 (21-10-2019)

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Alexandre Desaintjean, Sophia Belrhomari, Lidie Rousseau, Guillaume Lefèvre, Paul Knochel. Iron-Catalyzed Cross-Coupling of Functionalized Benzylmanganese Halides with Alkenyl Iodides, Bromides, and Triflates. Organic Letters, 2019, 21, pp.8684-8688. ⟨10.1021/acs.orglett.9b03292⟩. ⟨cea-02321208⟩
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