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Iron-Catalyzed Cross-Coupling of Functionalized Benzylmanganese Halides with Alkenyl Iodides, Bromides, and Triflates

Abstract : Various substituted benzylic manganese chlorides were prepared by insertion of magnesium turnings in the presence of MnCl2·2LiCl in THF at −5 °C within 2 h. These benzylic manganese reagents underwent smooth cross-couplings with various functionalized alkenyl iodides, bromides, and triflates or iodoacrylates in the presence of 10 mol % FeCl2 at 25 °C for 1–12 h. Mechanistic studies showed that benzylic manganese halides produced, in the presence of FeCl2, a very reactive iron ate complex.
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https://hal-cea.archives-ouvertes.fr/cea-02321208
Contributor : Serge Palacin <>
Submitted on : Monday, October 21, 2019 - 7:25:29 AM
Last modification on : Monday, February 10, 2020 - 6:13:58 PM

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Alexandre Desaintjean, Sophia Belrhomari, Lidie Rousseau, Guillaume Lefèvre, Paul Knochel. Iron-Catalyzed Cross-Coupling of Functionalized Benzylmanganese Halides with Alkenyl Iodides, Bromides, and Triflates. Organic Letters, American Chemical Society, 2019, 21, pp.8684-8688. ⟨10.1021/acs.orglett.9b03292⟩. ⟨cea-02321208⟩

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