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XNA ligation using T4 DNA ligase in crowding conditions

Abstract : T4 DNA ligase is capable of ligating 2OMe-RNA duplexes, HNA, LNA and FANA mixed sequences in the presence of 10% w/v PEG8000 and 3 M betaine. The enzymatic joining of oligonucleotides containing multiple consecutive XNA nucleotides at the ligation site has not been reported before.
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Submitted on : Wednesday, September 18, 2019 - 4:21:15 PM
Last modification on : Wednesday, June 17, 2020 - 3:42:03 PM

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Donaat Kestemont, Marleen Renders, Piotr Leonczak, Mikhail Abramov, Guy Schepers, et al.. XNA ligation using T4 DNA ligase in crowding conditions. Chemical Communications, Royal Society of Chemistry, 2018, 54 (49), pp.6408-6411. ⟨10.1039/c8cc02414f⟩. ⟨cea-02291354⟩



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