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Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Abstract : Background: Cell-to-cell propagation of α-synuclein ($\alpha$-syn) aggregates is thought to contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated microglia can promote α-syn aggregation. However, it is unclear how microglia influence α-syn cell-to-cell transfer.
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https://hal-cea.archives-ouvertes.fr/cea-02280706
Contributor : Mehdi Kabani <>
Submitted on : Friday, September 6, 2019 - 2:48:16 PM
Last modification on : Friday, July 3, 2020 - 11:52:03 AM

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Sonia George, Nolwen Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, et al.. Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease. Molecular Neurodegeneration, BioMed Central, 2019, 14, pp.34. ⟨10.1186/s13024-019-0335-3⟩. ⟨cea-02280706⟩

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