Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease - Archive ouverte HAL Access content directly
Journal Articles Molecular Neurodegeneration Year : 2019

Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

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Abstract

Background: Cell-to-cell propagation of α-synuclein ($\alpha$-syn) aggregates is thought to contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated microglia can promote α-syn aggregation. However, it is unclear how microglia influence α-syn cell-to-cell transfer.
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Dates and versions

cea-02280706 , version 1 (06-09-2019)

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Sonia George, Nolwen Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, et al.. Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease. Molecular Neurodegeneration, 2019, 14, pp.34. ⟨10.1186/s13024-019-0335-3⟩. ⟨cea-02280706⟩
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