Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Sonia George (1, 2) , Nolwen Rey (3, 4, 2) , Trevor Tyson (1, 2) , Corinne Esquibel (5, 2) , Lindsay Meyerdirk (1, 2) , Emily Schulz (1, 2) , Steven Pierce (1, 2) , Amanda R Burmeister (1, 2) , Zachary Madaj (6, 2) , Jennifer A Steiner (1, 2) , Martha L Escobar Galvis (1, 2) , Lena Brundin (3, 2) , Patrik Brundin (1, 2)

1 Center for neurodegenerative Science, Van Andel Research Institute
2 Van Andel Institute [Grand Rapids]
3 Center for Neurodegenerative Science, Van Andel Research Institute
4 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
5 Optical Image Core, Van Andel Research Institute
6 Bioinformatics and Biostatistics Core, Van Andel Research Institute

Background: Cell-to-cell propagation of α-synuclein ($\alpha$-syn) aggregates is thought to contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated microglia can promote α-syn aggregation. However, it is unclear how microglia influence α-syn cell-to-cell transfer.

Domains: Neurons and Cognition [q-bio.NC]; Cellular Biology; Biochemistry, Molecular Biology

Sonia George, Nolwen Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, et al.. Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease. Molecular Neurodegeneration, 2019, 14, pp.34. ⟨10.1186/s13024-019-0335-3⟩. ⟨cea-02280706⟩