Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

Maria Masnata; Giacomo Sciacca; Alexander Maxan; Luc Bousset; Hélèna Denis; Florian Lauruol; Linda David; Martine Saint-Pierre; Jeffrey Kordower; Ronald Melki; Melanie Alpaugh; Francesca Cicchetti

doi:10.1007/s00401-019-01973-6

Journal articles

Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

Maria Masnata ^{1, 2} Giacomo Sciacca ^{1, 2} Alexander Maxan ^{1, 2} Luc Bousset ³ Hélèna Denis ^{1, 2} Florian Lauruol ^{1, 2} Linda David ^{1, 2} Martine Saint-Pierre ^{1, 2} Jeffrey Kordower ⁴ Ronald Melki ³ Melanie Alpaugh ^{1, 2} Francesca Cicchetti ^{1, 2}

1 Axe Neurosciences [CHU Québec]

2 Departement de Psychiatrie & Neurosciences, Université Laval, Québec, QC, Canada

3 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199

MIRCEN - Service MIRCEN : DRF/JACOB, CNRS - Centre National de la Recherche Scientifique : UMR 9199

4 Department of Neurological Sciences, Rush University Medical Center, Chicago IL, USA

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Neurons and Cognition [q-bio.NC]

Life Sciences [q-bio] / Biochemistry, Molecular Biology

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https://hal-cea.archives-ouvertes.fr/cea-02279743
Contributor : Mehdi KABANI Connect in order to contact the contributor
Submitted on : Thursday, September 5, 2019 - 3:12:09 PM
Last modification on : Sunday, June 26, 2022 - 2:40:35 AM

Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

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Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

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