Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

Maria Masnata (1, 2) , Giacomo Sciacca (1, 2) , Alexander Maxan (1, 2) , Luc Bousset (3) , Hélèna Denis (1, 2) , Florian Lauruol (1, 2) , Linda David (1, 2) , Martine Saint-Pierre (1, 2) , Jeffrey Kordower (4) , Ronald Melki (3) , Melanie Alpaugh (1, 2) , Francesca Cicchetti (1, 2)

1 Axe Neurosciences [CHU Québec]
2 Departement de Psychiatrie & Neurosciences, Université Laval, Québec, QC, Canada
3 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
4 Department of Neurological Sciences, Rush University Medical Center, Chicago IL, USA

Domains: Neurons and Cognition [q-bio.NC]; Biochemistry, Molecular Biology

Maria Masnata, Giacomo Sciacca, Alexander Maxan, Luc Bousset, Hélèna Denis, et al.. Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms. Acta Neuropathologica, 2019, 137 (6), pp.981-1001. ⟨10.1007/s00401-019-01973-6⟩. ⟨cea-02279743⟩