LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Gregor Bieri (1) , Michel Brahic (1) , Luc Bousset (2) , Julien Couthouis (1) , Nicholas Kramer (1) , Rosanna Ma (1) , Lisa Nakayama (1) , Marie Monbureau (3, 4) , Erwin Defensor (3, 4) , Birgitt Schüle (5) , Mehrdad Shamloo (3, 4) , Ronald Melki (2) , Aaron Gitler (1)

1 Stanford School of Medicine [Stanford]
2 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
3 Stanford Behavioral and Functional Neuroscience Laboratory, Stanford University, Stanford, CA, USA
4 Department of Neurosurgery [Stanford]
5 Department of Pathology [Stanford]

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Life Sciences [q-bio]; Cellular Biology; Life Sciences [q-bio]; Biochemistry, Molecular Biology

Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas Kramer, et al.. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathologica, 2019, 137 (6), pp.961-980. ⟨10.1007/s00401-019-01995-0⟩. ⟨cea-02279704⟩