Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding, 1999. ,
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease, J. Biol. Chem, vol.281, pp.29739-29752, 2006. ,
Interplay between desolvation and secondary structure in mediating cosolvent and temperature induced alpha-synuclein aggregation, Phys. Biol, vol.9, p.56005, 2012. ,
Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding, 1999. ,
Post-translational modification of alpha-synuclein in Parkinson's disease, Brain Res, vol.1628, pp.247-253, 2015. ,
Polyunsaturated fatty acids and their metabolites in brain function and disease, Nat. Rev. Neurosci, vol.15, p.771, 2014. ,
Structural and functional characterization of two alpha-synuclein strains, Nat. Commun, vol.4, pp.1-13, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01183047
Alpha-synuclein induces both positive mean curvature and negative Gaussian curvature in membranes, J. Am. Chem. Soc, vol.134, pp.2613-2620, 2012. ,
Alpha-synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry, J. Am. Chem. Soc, vol.136, pp.9962-9972, 2014. ,
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease, Cell Rep, vol.9, pp.1135-1150, 2014. ,
Properties of native brain alpha-synuclein, Nature, vol.498, p.4, 2013. ,
Insights on the interaction of alphasynuclein and metals in the pathophysiology of Parkinson's disease, Metallomics, vol.7, pp.395-404, 2015. ,
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans, Neurosci. Lett, vol.319, pp.25-28, 2002. ,
Toxic prefibrillar alpha-synuclein amyloid oligomers adopt a distinctive antiparallel beta-sheet structure, Biochem. J, vol.443, pp.719-726, 2012. ,
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation, J. Clin. Investig, vol.119, pp.3257-3265, 2009. ,
Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade, Annu. Rev. Biochem, vol.86, pp.27-68, 2017. ,
Large alpha-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking, Proc. Natl Acad. Sci. USA, vol.110, pp.4087-92, 2013. ,
Accumulation of toxic alpha-synuclein oligomer within endoplasmic reticulum occurs in alpha-synucleinopathy in vivo, J. Neurosci, vol.32, pp.3301-3305, 2012. ,
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy, Proc. Natl Acad. Sci. USA, vol.97, pp.571-576, 2000. ,
Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants, Ann. N. Y. Acad. Sci, vol.920, pp.42-45, 2000. ,
Direct observation of the interconversion of normal and toxic forms of a-synuclein, Cell, vol.149, pp.1048-1059, 2012. ,
Structural characteristics of alpha-synuclein oligomers, International Review of Cell and Molecular Biology, vol.329, pp.79-143, 2017. ,
Different species of alpha-synuclein oligomers induce calcium influx and seeding, J. Neurosci, vol.27, pp.9220-9232, 2007. ,
Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology, J. Neurochem, vol.111, pp.192-203, 2009. ,
Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease, Antioxid. Redox Signal, vol.24, pp.376-391, 2016. ,
Two conformationally distinct in vitro a-synuclein oligomers share common epitopes and the ability to impair long-term potentiation, PLoS ONE, vol.14, 2019. ,
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes, Biochemistry, vol.41, pp.10209-10217, 2002. ,
Protein folding and misfolding, Nature, vol.426, p.884, 2003. ,
EGCG redirects amyloidogenic polypeptides into unstructured, offpathway oligomers, Nat. Struct. Mol. Biol, vol.15, p.558, 2008. ,
Conformational properties of alpha-synuclein in its free and lipid-associated states, J. Mol. Biol, vol.307, pp.1061-1073, 2001. ,
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic, Biol. Med, vol.11, pp.81-128, 1991. ,
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence, Proc. Natl Acad. Sci. USA, vol.106, pp.5645-5650, 2009. ,
Oxidants, oxidative stress and the biology of ageing, Nature, vol.408, p.239, 2000. ,
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins, Acta Neuropathol, vol.134, pp.629-653, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01571238
Structural and morphological characterization of aggregated species of alphasynuclein induced by docosahexaenoic acid, J. Biol. Chem, vol.286, pp.22262-22274, 2011. ,
Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of a-synuclein, Proteins, vol.78, pp.714-722, 2010. ,
Alpha-Synuclein is phosphorylated in synucleinopathy lesions, Nat. Cell Biol, vol.4, p.160, 2002. ,
Structural basis of membrane disruption and cellular toxicity by alpha-synuclein oligomers, Science, vol.358, pp.1440-1443, 2017. ,
Structural insights into amyloid oligomers of the Parkinson disease-related protein alpha-synuclein, J. Biol. Chem, vol.289, pp.26733-26742, 2014. ,
Altered machinery of protein synthesis is region-and stage-dependent and is associated with alpha-synuclein oligomers in Parkinson's disease, Acta Neuropathol. Commun, vol.3, p.76, 2015. ,
Lowresolution structure of a vesicle disrupting alpha-synuclein oligomer that accumulates during fibrillation, Proc. Natl Acad. Sci. USA, vol.108, pp.3246-3251, 2011. ,
Propagation of alpha-synuclein strains within human reconstructed neuronal network, Stem Cell Rep, vol.12, pp.230-244, 2019. ,
Cryo-EM structure of alpha-synuclein fibrils, vol.7, p.36402, 2018. ,
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease, Biochem. J, vol.471, pp.323-333, 2015. ,
Age-dependent accumulation of oligomeric SNCA/alpha-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), 2018. ,
Functional consequences of alpha-synuclein tyrosine nitration diminished binding to lipid vesicles and increased fibril formation, J. Biol. Chem, vol.279, pp.47746-47753, 2004. ,
Alpha-synuclein activates BV2 microglia dependent on its aggregation state, Biochem. Biophys. Res. Comm, vol.479, pp.881-886, 2016. ,
Copper (II)-induced self-oligomerization of a-synuclein, Biochem. J, vol.340, pp.821-828, 1999. ,
Cold denaturation of alpha-synuclein amyloid fibrils, Angew. Chem. Int. Ed Engl, vol.53, pp.7799-7804, 2014. ,
Alpha-synuclein oligomers-neurotoxic molecules in Parkinson's disease and other Lewy body disorders, Front. Neurosci, vol.10, p.408, 2016. ,
Single-particle characterization of iron-induced pore-forming alpha-synuclein oligomers, J. Biol. Chem, vol.283, pp.10992-1003, 2008. ,
AlaSOPro mutation in the gene encoding alpha-synuclein in Parkinson's disease, Nat. Genet, vol.18, p.106, 1998. ,
Novel a-synuclein aggregation inhibitors, identified by HTS, mainly target the monomeric state Cell, Chem. Biol, vol.25, pp.1389-1140, 2018. ,
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils, J. Mol. Biol, vol.322, pp.1089-1102, 2002. ,
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target, Nat. Rev. Neurosci, vol.14, p.38, 2013. ,
Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation, Chem. Res. Toxicol, vol.13, pp.698-702, 2000. ,
Dequalinium-induced protofibril formation of alpha-synuclein, J. Biol. Chem, vol.281, pp.3463-3472, 2006. ,
G51D alphasynuclein mutation causes a novel Parkinsonian-pyramidal syndrome, Ann. Neurol, vol.73, pp.459-471, 2013. ,
Cryo-EM of full-length alphasynuclein reveals fibril polymorphs with a common structural kernel, Nat. Commun, vol.9, p.3609, 2018. ,
Amyloid fibril structure of alphasynuclein determined by cryo-electron microscopy, Cell Res, vol.28, pp.897-903, 2018. ,
Proteasomal inhibition by alpha-synuclein filaments and oligomers, J. Biol. Chem, vol.279, pp.12924-12958, 2004. ,
Immunotherapy targeting alpha-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] alpha-synuclein mice, Neurobiol. Dis, vol.69, pp.134-143, 2014. ,
A novel molecular mechanism for nitrated alpha-synuclein-induced cell death, J. Mol. Cell Biol, vol.3, pp.239-249, 2011. ,
Alpha-synuclein promotes dilation of the exocytotic fusion pore, Nat. Neurosci, vol.20, p.681, 2017. ,
The role of stable alpha-synuclein oligomers in the molecular events underlying amyloid formation, J. Am. Chem. Soc, vol.136, pp.3859-3868, 2014. ,
How epigallogatechin gallate can inhibit a-synuclein oligomer toxicity in vitro, J. Biol. Chem, vol.289, pp.21299-21310, 2014. ,
Exogenous alphasynuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells, Proc. Natl Acad. Sci. USA, vol.106, pp.20051-20056, 2009. ,
Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice, Science, vol.338, pp.949-953, 2012. ,
Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative a-synucleinopathy in mice, J. Exp. Med, vol.209, pp.975-986, 2012. ,
Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein, J. Am. Chem. Soc, vol.126, pp.2399-2408, 2004. ,
Prion-like spreading of pathological alpha-synuclein in brain, Brain, vol.136, pp.1128-1138, 2013. ,
Remodeling of lipid vesicles into cylindrical micelles by alpha-synuclein in an extended alpha helical conformation, J. Biol. Chem, vol.287, pp.29301-29311, 2012. ,
The heat shock response: systems biology of proteotoxic stress in aging and disease, Cold Spring Harbor Symposia on Quantitative Biology, vol.76, pp.91-99, 2011. ,
Prion-like acceleration of a synucleinopathy in a transgenic mouse model, Neurobiol. Aging, vol.33, pp.2225-2228, 2012. ,
The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of alpha-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic, Biol. Med, vol.50, pp.428-437, 2011. ,
Alpha-synuclein has a high affinity for packing defects in a bilayer membrane a thermodynamics study, J. Biol. Chem, vol.279, pp.21966-21975, 2004. ,
Thermodynamics of the Polymerization of Protein, 1975. ,
Alpha-synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling, J. Biol. Chem, vol.288, pp.20883-20895, 2013. ,
Role of posttranslational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies, Progress in Brain Research, vol.183, issue.10, pp.83007-83016, 2010. ,
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits a-synuclein oligomerization, and influences synuclein-membrane interactions, J. Neurosci, vol.30, pp.3184-3198, 2010. ,
Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils, J. Am. Chem. Soc, vol.135, pp.7503-7510, 2013. ,
Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells, Int. J. Biochem. Cell Biol, vol.41, pp.2015-2024, 2009. ,
High stability and cooperative unfolding of cytotoxic a-synuclein oligomers, Biochemistry, vol.53, pp.6252-6263, 2014. ,
Co-existence of two different a-synuclein oligomers with different core structures determined by hydrogen/deuterium exchange mass spectrometry, Angew. Chem. Int. Ed Engl, vol.53, pp.7560-7563, 2014. ,
Formation and characterization of a-synuclein oligomers, Methods Mol. Biol, vol.1345, pp.133-150, 2016. ,
Alpha-synuclein strains cause distinct synucleinopathies after local and systemic administration, Nature, vol.522, p.340, 2015. ,
Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic alpha-synuclein administration, Front. Immunol, vol.10, p.80, 2019. ,
Fibrillar alphasynuclein and huntingtin exon 1 assemblies are toxic to the cells, Biophys. J, vol.102, pp.2894-2905, 2012. ,
Structural and functional properties of prefibrillar alpha-synuclein oligomers, Sci. Rep, vol.6, p.24526, 2016. ,
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease, Science, vol.276, pp.2045-2047, 1997. ,
Alpha-synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding, J. Cell. Biol, vol.194, pp.89-103, 2011. ,
A novel alpha-synuclein missense mutation in Parkinson disease, Neurology, vol.80, pp.1062-1064, 2013. ,
Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism, Proc. Natl Acad. Sci. USA, vol.112, pp.5308-5317, 2015. ,
Effect of 4-hydroxy-2-nonenal modification on alphasynuclein aggregation, J. Biol. Chem, vol.282, pp.5862-5870, 2007. ,
Lewy body extracts from Parkinson disease brains trigger alpha-synuclein pathology and neurodegeneration in mice and monkeys, Ann. Neurol, vol.75, pp.351-362, 2014. ,
Transfer of human alpha-synuclein from the olfactory bulb to interconnected brain regions in mice, Acta Neuropathol, vol.126, pp.555-573, 2013. ,
Widespread transneuronal propagation of alpha-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease, J. Exp. Med, vol.213, pp.1759-1778, 2016. ,
Tryptophan fluorescence reveals structural features of alpha-synuclein oligomers, J. Mol. Biol, vol.394, pp.826-833, 2009. ,
Conformational equilibria in monomeric a-synuclein at the single-molecule level, PLoS Biol, vol.6, p.6, 2008. ,
Hydrophobic-Interaction-Induced Stiffening of alpha-Synuclein Fibril Networks, Phys. Rev. Lett, vol.120, p.208102, 2018. ,
Propagation of pathological alpha-synuclein in marmoset brain, Acta Neuropathol. Commun, vol.5, p.12, 2017. ,
) alpha-Synuclein locus triplication causes Parkinson's disease, Science, vol.302, p.841, 2003. ,
Alpha-synuclein oligomers: an amyloid pore?, Mol. Neurobiol, vol.47, pp.613-621, 2013. ,
Structural disorder of monomeric alpha-synuclein persists in mammalian cells, Nature, vol.530, p.45, 2016. ,
Solid-state NMR structure of a pathogenic fibril of full-length human alphasynuclein, Nat. Struct. Mol. Biol, vol.23, pp.409-415, 2016. ,
A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders, J. Biomol. Struct. Dyn, vol.21, pp.211-234, 2003. ,
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein a possible molecular link between Parkinson's disease and heavy metal exposure, J. Biol. Chem, vol.276, pp.44284-44296, 2001. ,
Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins, J. Biol. Chem, vol.285, pp.32486-32493, 2010. ,
Pathological roles of alpha-synuclein in neurological disorders, Lancet Neurol, vol.10, pp.1015-1025, 2011. ,
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's diseaselinked mutations and occurs by a pore-like mechanism, Biochemistry, vol.41, pp.4595-4602, 2002. ,
Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death, Neuron, vol.72, pp.57-71, 2011. ,
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates, Neuropathology, vol.27, pp.494-506, 2007. ,
Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity, J. Neurochem, vol.113, pp.704-714, 2010. ,
Transmission of multiple system atrophy prions to transgenic mice, Proc. Natl Acad. Sci. USA, vol.110, pp.19555-19560, 2013. ,
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded, Biochemistry, vol.35, pp.13709-13715, 1996. ,
In vivo demonstration that alpha-synuclein oligomers are toxic, Proc. Natl Acad. Sci. USA, vol.108, pp.4194-4199, 2011. ,
Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers, FEBS Lett, vol.542, pp.147-152, 2003. ,
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease, Proc. Natl Acad. Sci. USA, vol.93, pp.2696-2701, 1996. ,
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia, Ann. Neurol, vol.55, pp.164-173, 2004. ,
Molecular composition of substoichiometrically labeled alpha-synuclein oligomers determined by single-molecule photobleaching, Angew. Chem, vol.124, pp.8951-8954, 2012. ,