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Cucurbit[5]uril derivatives as oxygen carriers

Gaspard Huber 1, * Patrick Berthault 1 Anvi Laetitia Nguyen 2 Alain Pruvost 2 Elodie Barruet 3 Julie Rivollier 4 Marie-Pierre Heck 4 Benoit Prieur
* Corresponding author
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
3 LIONS - Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : Cucurbit[n]urils are rigid cage-molecules of pumpkin-like shape, made of n-glycoluril units, able to bind mainly neutral molecules and cations. In this work, we investigate the binding of three cucurbit[5]uril derivatives with dioxygen O$_2$ and show that one of them, namely per-hydroxylated cucurbit[5]uril, (OH)$_{10}$CB[5], is able to significantly bind dioxygen gas at physiological temperature, even in the presence of sodium chloride at the concentration of injectable solution in blood. As cucurbit[n]urils studied up to now reveal low toxicity, per-hydroxylated cucurbit[5]uril appears as a promising precursor to design a host able to transport O$_2$ in a haemoglobin substitute solution.
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Gaspard Huber, Patrick Berthault, Anvi Laetitia Nguyen, Alain Pruvost, Elodie Barruet, et al.. Cucurbit[5]uril derivatives as oxygen carriers. Supramolecular Chemistry, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2019, 31 (10), pp.668-675. ⟨10.1080/10610278.2019.1655565⟩. ⟨cea-02273187⟩

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