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Standardized and modular microfluidic platform for fast Lab on Chip system development

Abstract : Since the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.
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Contributor : Marianne Leriche <>
Submitted on : Monday, July 15, 2019 - 4:14:03 PM
Last modification on : Thursday, June 11, 2020 - 5:04:08 PM

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S. Dekker, W. Buesink, M. Blom, M. Alessio, N. Verplanck, et al.. Standardized and modular microfluidic platform for fast Lab on Chip system development. Sensors and Actuators B: Chemical, Elsevier, 2018, 272, pp.468-478. ⟨10.1016/j.snb.2018.04.005⟩. ⟨cea-02183835⟩



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