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Journal Articles Sensors and Actuators B: Chemical Year : 2018

Standardized and modular microfluidic platform for fast Lab on Chip system development

S. Dekker
  • Function : Author
W. Buesink
  • Function : Author
M. Blom
  • Function : Author
M. Hihoud
  • Function : Author
C. Dehan
  • Function : Author
W. César
  • Function : Author
A. Le Nel
  • Function : Author
A. van den Berg
  • Function : Author
  • PersonId : 829321
M. Odijk
  • Function : Author

Abstract

Since the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.

Dates and versions

cea-02183835 , version 1 (15-07-2019)

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Cite

S. Dekker, W. Buesink, M. Blom, M. Alessio, N. Verplanck, et al.. Standardized and modular microfluidic platform for fast Lab on Chip system development. Sensors and Actuators B: Chemical, 2018, 272, pp.468-478. ⟨10.1016/j.snb.2018.04.005⟩. ⟨cea-02183835⟩
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